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Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH-sensitive drug release property

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成果类型:
期刊论文
作者:
Yu, Cui-Yun;Yin, Bio-Cheng;Zhang, Wei;Cheng, Si-Xue;Zhang, Xian-Zheng;Zhuo, Ren-Xi
通讯作者:
Cheng, S.-X.
作者机构:
[Yu, Cui-Yun] Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China
通讯机构:
[Cheng, Si-Xue] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China.
Key Laboratory of Biomedical Polymers, Ministry of Education, Department of Chemistry, China
语种:
英文
关键词:
Alginate;Chitosan;Controlled drug release;Microparticles;Pectin
期刊:
Colloids and Surfaces B: Biointerfaces
ISSN:
0927-7765
年:
2009
卷:
68
期:
2
页码:
245-249
基金类别:
National Natural Science Foundation of China [20774070]; Ministry of Education of China (Cultivation Fund of Key Scientific and Technical Innovation Project [707043]; Ministry of Science and Technology of China [2005CB623903]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH sensitivity were developed for oral delivery of protein drugs, using bovine serum albumin (BSA) as a model drug. The composite drug-loaded microparticles with a mean particle size less than 200 μm were prepared by a convenient shredding method. Since the microparticles were formed by tripolyphosphate cross-linking, electrostatic complexation by alginate and/or pectin, as well as ionotropic gelation with calcium ions, the microparticles exhibited an improved pH-sensitive drug release property. The in vitro drug release behaviors of the microparticles were studied in simulated gastric (pH 1.2 and pH 5.0), intestinal (pH 7.4) and colonic (pH 6.0 and pH 6.8 with enzyme) media. For the composite microparticles with suitable compositions, the releases of BSA at pH 1.2 and pH 5.0 could be effectively sustained, while the releases at pH 7.4, pH 6.8 and pH 6.0 increased significantly, especially in the presence of pectinase. These results clearly suggested that the microparticles had potential for site-specific protein drug delivery through oral administration. ©2008 Elsevier B.V. All rights reserved.

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