期刊论文

Li, Jianming;Tang, Yonghong

英文

Inflammation Research

1023-3830

2020

69

9

911-923

10.1007/s00011-020-01368-4

The present study was funded by the National Natural Science Foundation of China (Grant nos. 81873780, 61702054); Hunan Natural Science Foundation Youth Program (2019JJ50697, 2018JJ3568); The Changsha Outstanding Innovative Young People Training Scheme (kq1905047, kq1905045); The Foundation of the Education Department of Hunan Province (16A027, 19A058); The Foundation of Health and Family Planning Commission of Hunan Province (20201918); The Application Characteristic Discipline of Hunan Province; The Hunan Key Laboratory Cultivation Base of the Research and Development of Novel Pharmaceutical Preparations (No. 2016TP1029); The clinical research center of neurodegenerative diseases in Hunan province (2018SK4002); The Hunan Provincial Innovation Platform and Talents Program (No. 2018RS3105); The Hunan provincial science and technology department and Hunan provincial health and family planning commission (Grant No.[2018]85); The Natural science foundation of Hunan province (Grant No.[2017]1); The Key project of Hunan provincial commission of health and family planning (Grant No.[2017]144); The Hunan province science and technology major project (Grant No.[2016]158); Hunan Provincial Science and Technology Department Clinical Medical Technology Innovation Guide Project(2018SK51711).

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Objectives: Allergic rhinitis (AR) is a chronic inflammatory disease of nasal mucosa. Loss of function of Th17 cells and regulatory T (Treg) cells plays a role in the pathogenesis of AR. IL18, FOXP3, and IL13 are key genes in the development of AR. However, the genetic associations between IL18, FOXP3 and IL13 genes polymorphisms and AR risk were inconclusive yet. Methods: A meta-analysis was performed by searching through Pubmed, EMBASE, web of science and CNKI databases. The ORs and 95%CIs were used to assess the genetic association between t...