Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4-nuclear factor kappa B signaling

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成果类型：

期刊论文

作者：

Chi, Xinjin*;Wei, Xiaoxia;Gao, Wanling;Guan, Jianqiang;Yu, Xiaofan;...

通讯作者：

Chi, Xinjin

作者机构：

[Gao, Wanling; Cai, Jun; Chi, Xinjin; Guan, Jianqiang; Wei, Xiaoxia] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Anesthesiol, Guangzhou 510630, Guangdong, Peoples R China.

[Yu, Xiaofan] Fujian Prov Hosp, Dept Anesthesiol, Fuzhou 350001, Fujian, Peoples R China.

[Wang, Yiheng] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Li, Xi] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Thyroid & Breast Surg, Guangzhou 510630, Guangdong, Peoples R China.

通讯机构：

[Chi, Xinjin] S

Sun Yat Sen Univ, Affiliated Hosp 3, Dept Anesthesiol, Guangzhou 510630, Guangdong, Peoples R China.

语种：

英文

关键词：

Liver transplantation;Acute lung injury;Toll-like receptor 4;Dexmedetomidine

期刊：

Journal of Translational Medicine

ISSN：

1479-5876

年：

2015

卷：

期：

页码：

1-8

DOI：

10.1186/s12967-015-0554-5

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471892]; Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2014A030313199]; Science and Technology Project Foundation of Guangdong Province, China [2008B030301053, 2013B021800181]; Outstanding Young Teacher Training Program of Sun Yat-sen University, China [14ykpy24]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

BACKGROUND: To investigate whether pretreatment with dexmedetomidine (Dex) has a protective effect against acute lung injury (ALI) in an orthotopic autologous liver transplantation (OALT) rat model and to explore the mechanisms responsible for the protective effect of Dex against lung injury. METHODS: Forty-eight rats underwent OALT and were randomly divided into six groups (n = 8 in each group) that received 10 microg/kg Dex, 50 microg/kg Dex, 50 microg/kg Dex + nonspecific alpha2-adrenergic receptor (AR) antagonist atipamezole, 50 microg/kg Dex + specific alpha2B/C-AR antagonist ARC-239, 50 ...

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Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4-nuclear factor kappa B signaling

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