Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix-loop-helix-mediated dimer formation

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成果类型：

期刊论文

作者：

Tam, Heng-Keat;Konig, Patricia;Himpich, Stephanie;Ngu, Ngoc Dinh;Abele, Rupert;...

通讯作者：

Tam, HK

作者机构：

[Tam, Heng-Keat; Abele, Rupert; Tam, HK; Pos, Klaas M.; Himpich, Stephanie] Goethe Univ Frankfurt, Inst Biochem, D-60438 Frankfurt, Germany.

[Ngu, Ngoc Dinh; Konig, Patricia; Muller, Volker] Goethe Univ Frankfurt, Dept Mol Microbiol & Bioenerget, D-60438 Frankfurt, Germany.

[Ngu, Ngoc Dinh; Konig, Patricia; Muller, Volker] Goethe Univ Frankfurt, Inst Mol Biosci, D-60438 Frankfurt, Germany.

[Tam, Heng-Keat; Tam, HK] Univ South China, Hengyang Med Sch, Dept Med Microbiol, Hengyang 421002, Peoples R China.

通讯机构：

[Tam, HK ] G

Goethe Univ Frankfurt, Inst Biochem, D-60438 Frankfurt, Germany.

Univ South China, Hengyang Med Sch, Dept Med Microbiol, Hengyang 421002, Peoples R China.

语种：

英文

关键词：

Acinetobacter baumannii;mannitol;compatible solutes;dehydrogenase;phosphatase

期刊：

Proceedings of the National Academy of Sciences of the United States of America

ISSN：

0027-8424

年：

2022

卷：

119

期：

页码：

e2107994119

DOI：

10.1073/pnas.2107994119

基金类别：

Deutsche Forschungsgemeinschaft through DFG Research UnitGerman Research Foundation (DFG) [FOR 2251]; iNEXT - Horizon 2020 programme of the European Union [PID 7108]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Persistence of Acinetobacter baumannii in environments with low water activity is largely attributed to the biosynthesis of compatible solutes. Mannitol is one of the key compatible solutes in A. baumannii, and it is synthesized by a bifunctional mannitol- 1-phosphate dehydrogenase/phosphatase (AbMtlD). AbMtlD catalyzes the conversion of fructose-6-phosphate to mannitol in two consecutive steps. Here, we report the crystal structure of dimeric AbMtlD, constituting two protomers each with a dehydrogenase and phosphatase domain. A proper assembly...

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Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix-loop-helix-mediated dimer formation

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