期刊论文

Chen, Zhao;Jiang, H

英文

Journal of Neurology

0340-5354

2023

270

9

4248-4261

10.1007/s00415-023-11741-y

This study was funded by the National Key R&D Program of China (No. 2021YFA0805200 to H Jiang), the National Natural Science Foundation of China (No. 81974176 and No. 82171254 to H Jiang; No.81901305 to C Wang), the Innovation Research Group Project of Natural Science Foundation of Hunan Province (No.2020JJ1008 to H Jiang), the Scientific Research Foundation of Health Commission of Hunan Province (No. B2019183 to H Jiang), the Key Research and Development Program of Hunan Province (No. 2020SK2064 to H Jiang), the Innovative Research and Development Program of Development and Reform Commission of Hunan Province to H Jiang, the Natural Science Foundation of Hunan Province (No. 2022JJ20094 and No.2021JJ40974 to Z Chen; No.2020JJ5925 to C Wang; No.2022JJ40783 to L He), the Central South University Research Programme of Advanced Interdisciplinary Study (No. 2023QYJC010 to H Jiang), the Project Program of National Clinical Research Center for Geriatric Disorders (Xiangya Hospital, No.2020LNJJ12 to H Jiang), the Science and Technology Innovation Program of Hunan Province (2022RC1027 to Z Chen).

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BACKGROUND: The longitudinal dynamics of neurofilament light chain (NfL) in multiple system atrophy (MSA) were incompletely illuminated. This study aimed to explore whether the plasma NfL (pNfL) could serve as a potential biomarker of clinical diagnosis and disease progression for MSA. METHODS: We quantified pNfL concentrations in both a large cross-sectional cohort with 214 MSA individuals, 65 PD individuals, and 211 healthy controls (HC), and a longitudinal cohort of 84 MSA patients. Propensity score matching (PSM) was used to balance the age between the three groups. The pNfL levels between...