Role of silent information regulator 1 in the protective effect of hydrogen sulfide on homocysteine-induced cognitive dysfunction: Involving reduction of hippocampal ER stress

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成果类型：

期刊论文

作者：

Tang, Yi-Yun;Wang, Ai-Ping;Wei, Hai-Jun;Li, Man-Hong;Zou, Wei*;...

通讯作者：

Tang, Xiao-Qing;Zou, Wei

作者机构：

[Wang, Ai-Ping; Wei, Hai-Jun; Wang, Chun-Yan; Li, Man-Hong; Tang, Xiao-Qing; Zou, Wei; Li, Xiang; Tang, Yi-Yun; Zhang, Ping] Univ South China, Inst Neurosci, Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Wei, Hai-Jun; Tang, Xiao-Qing; Tang, Yi-Yun] Univ South China, Dept Physiol, Med Coll, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Wang, Ai-Ping] Univ South China, Dept Anat, Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Li, Man-Hong; Tang, Xiao-Qing; Zou, Wei; Zhang, Ping] Univ South China, Nanhua Affiliated Hosp, Dept Neurol, 336 E Dongfeng Rd, Hengyang 421001, Hunan, Peoples R China.

[Li, Xiang] Univ South China, Dept Anaesthesiol, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Zou, Wei] U

Univ South China, Dept Physiol, Med Coll, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Nanhua Affiliated Hosp, Dept Neurol, 336 E Dongfeng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Neurosci, Med Coll, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Hydrogen sulfide;Homocysteine;Silent mating type information regulation 2 homolog 1;Endoplasmic reticulum stress;Cognitive dysfunction

期刊：

Behavioural Brain Research

ISSN：

0166-4328

年：

2018

卷：

342

期：

页码：

35-42

DOI：

10.1016/j.bbr.2017.12.040

基金类别：

This study was supported by Natural Science Foundation of China ( 81671057 , 81771178 ), the Major Research Topics of the Health and Family Planning Commission of Hunan province ( A2017020 ), and the Key Projects of the Education Department of Hunan province ( 17A187 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Homocysteine (Hcy) causes cognitive deficits and hippocampal endoplasmic reticulum (ER) stress. Our previous study has confirmed that Hydrogen sulfide (H2S) attenuates Hcy-induced cognitive dysfunction and hippocampal ER stress. Silent information regulator 1 (Sirt-1) is indispensable in the formation of learning and memory. Therefore, the aim of this study was to explore the role of Sirt-1 in the protective effect of H2S against Hcy-induced cognitive dysfunction. We found that NaHS (a donor of H2S) markedly up-regulated the expression of Sirt-1 in the hippocampus of Hcy-exposed rats. Sirtinol...

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Role of silent information regulator 1 in the protective effect of hydrogen sulfide on homocysteine-induced cognitive dysfunction: Involving reduction of hippocampal ER stress

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