One-Pot Synthesis of Enzyme and GSH Dual-Responsive Zwitterionic Copolymers with Cross-Linked Shells for Enhanced Anticancer Drug Delivery

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Fangjun;Wang, Jiaqi;Qin, Yang;Huang, Bo;Liu, Chaoyi;...

通讯作者：

Yu, CY;Yu, Cui-Yun;Wei, H

作者机构：

[Yu, Cui-Yun; Liu, Fangjun] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China.

[Wei, Hua; Yu, Cui-Yun; Zhang, Huiru; Huang, Bo; Wei, H; Qin, Yang; Wang, Jiaqi; Liu, Chaoyi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.

[Wei, Hua; Yu, Cui-Yun; Zhang, Huiru; Huang, Bo; Wei, H; Qin, Yang; Wang, Jiaqi; Liu, Chaoyi] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Wang, Jiaqi] Hunan Univ Med, Hunan Prov Key Lab Dong Med, Huaihua 418000, Peoples R China.

通讯机构：

[Yu, CY; Wei, H ] U

[Yu, CY ] Z

Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.

Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

enzyme-responsive;GSH-responsive;cross-linked shells;unimolecular micelles;anticancer drug delivery

期刊：

ACS APPLIED POLYMER MATERIALS

ISSN：

2637-6105

年：

2025

卷：

期：

页码：

2061–2072

DOI：

10.1021/acsapm.4c03864

基金类别：

Natural Science Foundation of Hunan Province [82373826]; National Natural Science Foundation of China [2023SK2043, 2021SK2036]; Key R&D Program of Hunan Province [220XQD106]; University of South China [2023JJ40570, 2023JJ50138, 2022JJ40381]; Hunan Provincial Natural Science Foundation of China

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Cross-linked polymeric micelles capable of undergoing de-cross-linking triggered by tumor microenvironment (TME) provide a solution to the extracellular stability vs intracellular destabilization dilemma of nanomedicine. Herein, we reported a simple yet effective strategy for the one-pot construction of enzyme and glutathione (GSH) dual-responsive zwitterionic copolymer micelles consisting of hydrophobic enzyme-degradable polytyrosine (PTyr) cores and cross-linked zwitterionic poly(oligo(ethylene glycol)monomethyl ether methacrylate- co -sulfobetaine methacrylate- co -disulfide dimethacrylate)...

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One-Pot Synthesis of Enzyme and GSH Dual-Responsive Zwitterionic Copolymers with Cross-Linked Shells for Enhanced Anticancer Drug Delivery

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