A let-7b binding site SNP in the 3 \'-UTR of the Bcl-xL gene enhances resistance to 5-fluorouracil and doxorubicin in breast cancer cells - 成果

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A let-7b binding site SNP in the 3 '-UTR of the Bcl-xL gene enhances resistance to 5-fluorouracil and doxorubicin in breast cancer cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Ting;Huang, Bin;Guo, Rui;Ma, Jin;Peng, Cuiying;...

通讯作者：

Lei, Xiaoyong

作者机构：

[Wang, Ting; Guo, Rui; Peng, Cuiying; Lei, Xiaoyong; Ma, Jin] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Wang, Ting] Univ South China, Affiliated Hosp 2, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Tang, Huifang; Huang, Bin; Zu, Xuyu] Univ South China, Affiliated Hosp 1, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Lei, Xiaoyong] Univ South China, Inst Pharm & Pharmacol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Lei, Xiaoyong] U

Univ South China, Inst Pharm & Pharmacol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

B-cell lymphoma-extra large;breast cancer;let-7b;resistance;single nucleotide polymorphism

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2015

卷：

期：

页码：

1907-1911

DOI：

10.3892/ol.2015.2938

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372579, 31371277, 30900625]; Colleges and Universities Innovation Platform Open Fund Project of Hunan Province of China [13K084]; Science and Technology Program fund of Hunan Province of China [212FJ2016]; Provincial Key Discipline for Pharmacy of Hunan Province of China during the Twelfth Five-year Plan Period

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

The development of acquired resistance to chemotherapy is a major obstacle in the successful treatment of cancer. In breast cancer cells, B-cell lymphoma-extra large (Bcl-xL) is involved in the development of resistance to various chemotherapeutic agents; therefore, preliminary biological prediction was performed to identify a putative binding site for let-7b in the 3'-untranslated region (UTR) of the Bcl-xL gene and a single nucleotide polymorphism (SNP) within this binding region. The present study investigated the association between the SNP...

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A let-7b binding site SNP in the 3 '-UTR of the Bcl-xL gene enhances resistance to 5-fluorouracil and doxorubicin in breast cancer cells

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