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Target-based metabolomics for the quantitative measurement of 37 pathway metabolites in rat brain and serum using hydrophilic interaction ultra-high-performance liquid chromatography-tandem mass spectrometry

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成果类型:
期刊论文
作者:
Chen, Jiahui;Hou, Waner;Han, Bo;Liu, Guanghui;Gong, Jin;...
通讯作者:
Liao, Qiongfeng;Xie, Zhiyong
作者机构:
[Chen, Jiahui; Gong, Jin; Liao, Qiongfeng; Liu, Guanghui; Hou, Waner] Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Guangzhou 510407, Guangdong, Peoples R China.
[Han, Bo] Shihezi Univ, Sch Pharm, Shihezi 832000, Peoples R China.
[Zhong, Danmin; Li, Yemeng; Xie, Zhiyong] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.
[Xie, Zhiyong] Univ South China, Cooperat Innovat Ctr Mol Target New Drug Study, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Liao, Qiongfeng] G
[Xie, Zhiyong] S
[Xie, Zhiyong] U
Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Guangzhou 510407, Guangdong, Peoples R China.
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.
语种:
英文
关键词:
Amino acids;HILIC-MS;Quantitative;Target-based metabolomics;neurotransmitters;purines and pyrimidines
期刊:
Analytical and Bioanalytical Chemistry
ISSN:
1618-2642
年:
2016
卷:
408
期:
10
页码:
2527-2542
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473319, 81473540]; Science and Technology Project of Guangdong Province [2014A02020902, 2014A020221027, 2015A030401031]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2015A030313123]
机构署名:
本校为通讯机构
院系归属:
药学与生物科学学院
摘要:
Amino acids, neurotransmitters, purines, and pyrimidines are bioactive molecules that play fundamental roles in maintaining various physiological functions. Their metabolism is closely related to the health, growth, development, reproduction, and homeostasis of organisms. Most recently, comprehensive measurements of these metabolites have shown their potential as innovative approaches in disease surveillance or drug intervention. However, simultaneous measurement of these metabolites presents great difficulties. Here, we report a novel quantita...

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