National Natural Science Foundation of China [22271244, 22071211]; Scientific Research Fund of Education Department of Hunan Province [21A0079]; Open Research Fund of School of Chemistry and Chemical Engineering and Henan Normal University [2022C02]
机构署名：
本校为通讯机构
院系归属：
化学化工学院
摘要：
The incorporation of gem-difluoromethylene units into organic molecules remains a formidable challenge. Conventional methodologies for constructing aryldifluoromethyl derivatives relied on the use of high-functional fluorinating regents under harsh conditions. Herein, we report general and efficient photoredox catalytic systems for defluoroalkylation of readily available trifluoromethylarenes through selective C-F cleavage to deliver gem-difluoromethyl radicals which proceed through reductive addition to both electron-donating and withdrawing alkenes under transition-metal free conditions. Mec...
