期刊论文

Wu, Minghua

英文

Brain Research

0006-8993

2011

1391

125-131

10.1016/j.brainres.2011.03.042

This study was supported by grants from the National Key Project of Scientific Research Program in China ( 2006CB910502 , 2006CB910504 ), the 111 Project ( 111-2-12 ), the National Science Foundation of China ( 30770825 , 30901718 ) and the Program for New Century Excellent Talents in University ( NCET-08-0562 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

本校为其他机构

POTE ankyrin domain family, member H (POTEH) belongs to POTE family, which expresses in many cancers. In this study, methylation status of POTEH promoter and its correlation with clinicopathological parameters were evaluated in glioma tissues and cells. Bisulfite sequencing PCR was carried out to investigate the promoter methylation status of POTEH in tumor of 96 glioma patients and glioma cells U251, SF767, and SF126. The effect of promoter hypomethylation on protein expression was evaluated by immunohistochemistry. POTEH was hypomethylated in...