The self-absorption of cellulose acetate microfiltration membrane with alpha radioactive 222Rn, 220Rn progeny have been studied by simulating the alpha spectroscopy-based measurement method procedure of hybrid 222Rn, 220Rn progeny. The experimental results show that, the difference of membrane self-absorption between 222Rn progeny and 220Rn progeny is very small and doesn't vary with membrane, and can take 0.978 as alpha Spectroscopy (or gross alpha counting method)'s membrane self-absorption factor when measuring concentration of hybrid 222Rn ...