Metformin inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes through IGF-IR/PI3K/AKT/m-TOR pathway

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成果类型：

期刊论文

作者：

Chen, Kun;Lin, Zhao-Wei;He, Sheng-mao;Wang, Cheng-qiang;Yang, Jian-cheng;...

通讯作者：

Li, Qi

作者机构：

[Lin, Zhao-Wei; Wang, Cheng-qiang; Li, Qi; Lu, Yao; Xie, Xiao-bo; Chen, Kun; Yang, Jian-cheng] Southern Med Univ, Zhujiang Hosp, Dept Orthoped, Guangzhou 510282, Guangdong, Peoples R China.

[Chen, Kun] Guangzhou Med Univ, Huizhou Third Peoples Hosp, Dept Orthoped, Huisshou 516002, Guangdong, Peoples R China.

[He, Sheng-mao] Univ South China, Affiliated Hosp 2, Dept Orthoped, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, Qi] S

Southern Med Univ, Zhujiang Hosp, Dept Orthoped, Guangzhou 510282, Guangdong, Peoples R China.

语种：

英文

关键词：

Metformin;Proliferation;Cell cycle;Rheumatoid arthritis;Fibroblast-like synoviocytes;IGF-IR /PI3K/AKT/ mTOR pathway

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2019

卷：

115

页码：

108875

DOI：

10.1016/j.biopha.2019.108875

基金类别：

Major State Basic Research Development Program of China (973 Program)National Basic Research Program of China [2014CB541800]

机构署名：

本校为其他机构

摘要：

Rheumatoid arthritis (RA) is a chronic autoimmune disease in which synovial fibroblast-like cells (FLSs) play an important role in RA development and is known to be lack of effective therapy. Thus, novel therapeutic strategies are greatly needed for treatment of RA. Metformin, a first-line drug for the treatment of type 2 diabetes, has been reported to inhibit the proliferation of a variety of tumor cells. In this study, we demonstrated that metformin could inhibit the RA-FLS proliferation in dose- and time-dependent manner. Our cell viability ...

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Metformin inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes through IGF-IR/PI3K/AKT/m-TOR pathway

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