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The Development of Yellow Mealworm (Tenebrio molitor) as a Cheap and Simple Model to Evaluate Acute Toxicity, Locomotor Activity Changes, and Metabolite Profile Alterations Induced by Nanoplastics of Different Sizes

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成果类型:
期刊论文
作者:
Sun, Miao;Zhao, Xiaomei;Luo, Sihuan;Jiang, Miao;Liu, Qing;...
通讯作者:
Cao, Y
作者机构:
[Zhao, Xiaomei; Cao, Yi; Sun, Miao; Luo, Sihuan] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang, Peoples R China.
[Jiang, Miao] Univ South China, Hengyang Med Coll, Hunan Int Sci & Technol Cooperat Base Arterioscler, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan P, Hengyang, Peoples R China.
[Liu, Qing] Shanghai AB Sciex Analyt Instrument Trading Co Ltd, Shanghai, Peoples R China.
通讯机构:
[Cao, Y ] U
Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang, Peoples R China.
语种:
英文
关键词:
acute toxicity;locomotor activity;metabolite profiles;nanoplastics;yellow mealworm (Tenebrio molitor)
期刊:
Journal of Applied Toxicology
ISSN:
0260-437X
年:
2025
基金类别:
The authors received no specific funding for this work.
机构署名:
本校为第一且通讯机构
院系归属:
医学院
公共卫生学院
摘要:
Due to the wide uses of plastic products, nanoplastics are ubiquitous contaminants in the environment. Hence, extensive studies used various models to evaluate the toxicity of nanoplastics. In the present study, we developed yellow mealworm (Tenebrio molitor) as an alternative model to investigate the acute toxicity of nanoplastics. Our results showed that microinjection with 500 mg/kg nanoplastics significantly increased death rate of yellow mealworms after 24 or 48 h, with 100 nm particles being more effective compared with 20 nm ones. Me...

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