The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice

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成果类型：

期刊论文

作者：

Li, Shuoshuo*;Hu, Wenyu;Gong, Shenghui;Zhang, Ping;Cheng, Jinbo;...

通讯作者：

Li, SS;Li, Shuoshuo;Yuan, ZQ

作者机构：

[Li, SS; Li, Shuoshuo] Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China.

[Wang, Yingyi; Shi, Wenjun; Yuan, ZQ; Wang, Shukun; Gong, Shenghui; Hu, Wenyu; Li, Shuoshuo; Li, Qianqian; Cheng, Jinbo; Yuan, Zengqiang; Li, SS; Zhang, Ping] Beijing Inst Basic Med Sci, Brain Sci Ctr, Beijing 100850, Peoples R China.

[Hu, Wenyu; Zhang, Ping] Univ South China, Sch Med, Hengyang 421001, Peoples R China.

[Shi, Wenjun; Cheng, Jinbo] Minzu Univ China, Coll Life & Environm Sci, Ctr Translat Neurosci, Beijing 100081, Peoples R China.

[Wang, Fengchao] Natl Inst Biol Sci, Beijing 102206, Peoples R China.

通讯机构：

[Li, SS ; Li, SS; Yuan, ZQ ] B

Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China.

Beijing Inst Basic Med Sci, Brain Sci Ctr, Beijing 100850, Peoples R China.

语种：

英文

关键词：

COL12A1;N6-methyladenosine;cognitive defect;hypoxia;proline-rich coiled-coil 2B;vascular remodeling

期刊：

Advanced Science

ISSN：

2198-3844

年：

2023

卷：

期：

页码：

2300892-

DOI：

10.1002/advs.202300892

基金类别：

National Natural Science Foundation of China [82230042, 81930029]; Fundamental Research Funds for the Central Universities [2023-JYB-XJSJJ010]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

High altitude exposure leads to various cognitive impairments. The cerebral vasculature system plays an integral role in hypoxia-induced cognitive defects by reducing oxygen and nutrition supply to the brain. RNA N6-methyladenosine (m6A) is susceptible to modification and regulates gene expression in response to environmental changes, including hypoxia. However, the biological significance of m6A in endothelial cell performance under hypoxic conditions is unknown. Using m6A-seq, RNA immunoprcipitation-seq, and transcriptomic co-analysis, the molecular mechanism of vascular system remodeling un...

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The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice

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