The YTH domain-containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Fenghe;Zeng, Chong;Liu, Jie;Wang, Lei;Yuan, Xiaorui;...

通讯作者：

Xia, XM;Huang, W

作者机构：

[Xia, XM; Yuan, Xiaorui; Xia, Xiaomeng; Li, Fenghe] Cent South Univ, Xiangya Hosp 2, Dept Gynaecol & Obstet, Changsha, Peoples R China.

[Zeng, Chong] Univ South China, Affiliated Hosp 7, Hengyang Med Sch, Dept Resp & Crit Care Med, Changsha, Hunan, Peoples R China.

[Liu, Jie] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Pathol, Changsha, Hunan, Peoples R China.

[Wang, Lei] Cent South Univ, Canc Res Inst, Sch Basic Med Sci, NHC Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China.

[Wang, Lei] Cent South Univ, Sch Basic Med Sci, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ,Canc Res Inst, Changsha, Hunan, Peoples R China.

通讯机构：

[Xia, XM ; Huang, W ] C

Cent South Univ, Xiangya Hosp 2, Dept Gynaecol & Obstet, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha, Peoples R China.

语种：

英文

关键词：

anti-tumour immunity;immunoregulation;m6A methylation;YTH domain-containing protein family

期刊：

Clinical and Translational Medicine

ISSN：

2001-1326

年：

2024

卷：

期：

页码：

e1784-

DOI：

10.1002/ctm2.1784

基金类别：

National Natural Science Foundation of China [82172678]; Natural Science Foundation of Hunan Province [2021JJ31034, 2023JJ30733, 2024JJ9194, 2023JJ30887]; Health Research Project of Hunan Provincial Health Commission [W20243220]; Natural Science Foundation of Changsha Municipal [kq2208312]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The YTH domain protein family regulates innate and adaptive immunity through regulating multiple immune cells and plays a role in anti‐tumour immunity. The YTH domain protein family influences the tumour immune microenvironment by targeting YAP and metabolic mechanisms, promoting immune escape and metastasis. The YTH domain protein family is a potential target for immune‐related diseases and tumour immunotherapy. Abstract Background The modification of N6‐methyladenosine (m6A) plays a pivotal role in tumor by altering both innate and adaptiv...

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The YTH domain-containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

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