期刊论文

Zhang, F.;Jiang, Z.

英文

FRONTIERS IN CARDIOVASCULAR MEDICINE

2297-055X

2023

10

1116509

10.3389/fcvm.2023.1116509

This study was supported by Postgraduate Scientific Research Innovation Project of Hunan Province (CX20221022 to ZT), National Natural Science Foundation of China (91839103, 81670429, 81470435 to ZJ), and “Double First-Class” project for innovative Group of Basic Medicine, University of South China (to ZJ).

本校为其他机构

Cardiovascular disease (CVD) is the number one cause of death in the world and seriously threatens human health. Pyroptosis is a new type of cell death discovered in recent years. Several studies have revealed that ROS-induced pyroptosis plays a key role in CVD. However, the signaling pathway ROS-induced pyroptosis has yet to be fully understood. This article reviews the specific mechanism of ROS-mediated pyroptosis in vascular endothelial cells, macrophages, and cardiomyocytes. Current evidence shows that ROS-mediated pyroptosis is a new target for the prevention and treatment of cardiovascul...