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Referential modification strategy based on phenolic hydroxyl-containing KSA luminogens for ER-targeting probe construction

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成果类型:
期刊论文
作者:
Deng, Qiyun;Ding, Keke;Li, Yin;Jiao, Yawen;Hu, Rong;...
通讯作者:
Wang, Zhiming(wangzhiming@scut.edu.cn);Hu, Rong(hurong@usc.edu.cn);Zhang, Tian(tzhang@sdut.edu.cn)
作者机构:
[Deng, Qiyun; Hu, Rong; Wang, Zhiming; Li, Yin; Tang, Ben Zhong] South China Univ Technol, AIE Inst, Ctr Aggregat Induced Emiss, State Key Lab Luminescent Mat & Devices,Guangdong, Guangzhou 510640, Peoples R China.
[Hu, Rong] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
[Jiao, Yawen; Zhang, Tian] Shandong Univ Technol, Sch Chem & Chem Engn, Zibo 255049, Peoples R China.
[Tang, Ben Zhong] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China.
[Ding, Keke] First Affiliated Hosp Wannan Med Coll, Yijishan Hosp Wannan Med Coll, Dept Urol, 2 Zheshan Rd, Wuhu 241001, Peoples R China.
通讯机构:
[Rong Hu; Zhiming Wang] C
Center for Aggregation-Induced Emission, AIE Institute, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou, 510640, PR China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou, 510640, PR China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, PR China
语种:
英文
关键词:
Aggregation-induced emission;Endoplasmic reticulum targeting;Keto-salicylaldehyde azine;Phenolic hydroxyl;Photo-dynamic therapy
期刊:
Biomaterials
ISSN:
0142-9612
年:
2022
卷:
289
页码:
121767
基金类别:
National Key R & D Program of China [2017YFE0132200]; National Natural Science Foundation of China [21788102, 21975077, 21907034, 21703122]; Natural Science Foundation of Guangdong Province [2022B1515020084, 2020A1515011542]; Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates [2019B030301003]; Open Research Project of Military Lo- gistics Support Department [BLB19J008]; independent research project of State Key Lab of Luminescent Materials and Devices (SCUT) [Skllmd-2022-01]
机构署名:
本校为其他机构
院系归属:
化学化工学院
摘要:
The endoplasmic reticulum (ER) plays essential roles in various physiological processes and is intimately connected to kinds of diseases. The development of ER-targeting theranostic agents is highly demanded for precise treatments, however, the effective and referential strategies for the construction of ER-targeting probes are limited. Herein, we developed series of ER-targeting luminogens based on keto-salicylaldehyde azine (KSA) framework by introducing phenolic hydroxyl group, which present good theranostic performance with selective enrichment in ER. Under systematical structure modulatio...

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