FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fu, Yu;Lin, Youcheng;Yang, Zhao;Yang, Guosheng*;Li, Gaoyuan;...

通讯作者：

Yang, Guosheng

作者机构：

[Liu, Yuejia; Fu, Yu; Bai, Jian; Li, Gaoyuan; Zeng, Jun; Yang, Guosheng; Cai, Yangke] Univ South China, Collaborat Hosp, Guangdong Prov Peoples Hosp 2, Dept Urol, Guangzhou 510317, Guangdong, Peoples R China.

[Tan, Xi] Univ South China, Collaborat Hosp, Guangdong Prov Peoples Hosp 2, Dept Pathol, Guangzhou 510095, Guangdong, Peoples R China.

[Lin, Youcheng; Ge, Yukun; Wu, Xun] Southern Med Univ, Guangzhou 510280, Guangdong, Peoples R China.

[Yang, Zhao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Huang, Yi; Fang, Lu; Wang, Yongqiang; Wu, Song; Zhang, Meng] Shenzhen Univ, Peoples Hosp 2, Natl Reg Key Technol Engn Lab Clin Applicat Canc, Affiliated Hosp 1, Shenzhen 518035, Peoples R China.

通讯机构：

[Yang, Guosheng] U

Univ South China, Collaborat Hosp, Guangdong Prov Peoples Hosp 2, Dept Urol, Guangzhou 510317, Guangdong, Peoples R China.

语种：

英文

关键词：

Apoptosis;Cell cycle;FBXW7;Proliferation;RCC

期刊：

Medical Oncology

ISSN：

1357-0560

年：

2015

卷：

期：

页码：

215

DOI：

10.1007/s12032-015-0656-1

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

FBXW7 gene (F-box and WD-40 domain protein 7) is also named HCDC4 and is a significant tumor suppressor gene, which can regulate human cell cycle, proliferation and differentiation. In this study, we tend to investigate protein expression and related biological functions of FBXW7 gene. FBXW7 expression level in renal cell carcinoma (RCC) tissues is highly related to its clinical pathologic grade (P = 0.0094) and TNM phase (P = 0.0080) and is highly lower than in paracancerous normal tissues through immunohistochemistry study. FBXW7 high-expression patients have overall better prognosis than lo...

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FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis

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