In order to study the application of nanofluids for enhancing heat transfer in the field of liquid-cooled data centers, a mathematical and physical model of liquid-cooled servers was established in this paper. FC–40 was used as the server cooling liquid base, and simulation studies were conducted on the flow and heat transfer of five types of nanofluid: Cu–FC40, CuO–FC40, Al–FC40, Al2O3–FC40, and TiO2–FC40. The results showed that using Al–FC40 nanofluids as the cooling medium had the best heat transfer effect. Under the same operating c...