Lipoprotein lipase(LPL) can hydrolyze triglycerides and provide energy for the development of tumor. Chronic lymphocytic leukaemia(CLL) is a malignant hematologic tumor caused by excessive proliferation of B lymphocytes and is characterized by the accumulation of lymphocytes in peripheral blood, bone marrow, spleen and lymph nodes. Studies have shown that the level of LPL in B lymphocytes is related to the prognosis of CLL patients. In this review, we mainly focused on the impacts of LPL on the occurrence and development of CLL and its clinical value to r...