期刊论文

The treatment of atherosclerosis through regulation of autophagy by AMPK agonists

中文

生命的化学

1000-1336

2020

40

7

1107-1113

10.13488/j.smhx.20200016

国家自然科学基金项目(81670401) 湖南省自然科学基金项目(2019JJ40248)。

本校为其他机构

动脉粥样硬化(atherosclerosis,As)是冠心病、脑梗死、外周血管病变等心血管疾病的重要病理基础。腺苷酸活化蛋白激酶(AMPK)作为药物靶标及生物能量代谢调节的关键分子,是治疗心血管疾病的潜在靶点,调控其活性可望成为心血管疾病治疗的有效策略。As斑块部位存在自噬,调控自噬可影响As的发生发展,而AMPK又可通过多种途径在自噬中发挥重要作用。因此,本文以自噬为出发点,总结了AMPK可通过调控炎症反应、减少脂质浸润等多个方面影响As进程的相关机制,以及AMPK激动剂在影响As方面的进展进行综述,为治疗As相关心血管疾病的方案提供了新的角度。

Atherosclerosis(As)is an important pathological basis for cardiovascular diseases such as coronary heart disease,cerebral infarction and peripheral vascular disease.As a drug target and a key molecule in the regulation of biological energy metabolism,adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)is a potential target for the treatment of cardiovascular disease.Regulation of AMPK activity is expected to be a promising method in the treatment of cardiovascular diseases.Studies have shown that there is autophagy in the atherosclerotic plaque,which can affect the occurrence and dev...