Sepsis refers to the systemic inflammatory response syndrome caused by severe infection. It is often life threatening multiple organ dysfunction in patient due to body's unbalanced response to infection. Recent studies have found that high-density lipoprotein (HDL) played important roles in regulating vascular endothelial cell function and immunity, and septic shock could be prevented by increasing circulating HDL levels. In this paper, we reviewed the possible mechanisms for protection against sepsis by HDL, and the prospects and challenge...
