期刊论文

中文

生命的化学

1000-1336

2018

38

4

565-569

10.13488/j.smhx.20180409

81572011:国家自然科学基金 31600150:国家自然科学基金 2016JJ3103:国家自然科学基金

本校为第一机构

衣原体是一种专性胞内寄生的原核细胞型微生物,是感染人和动物常见的病原体之一,能引起人类和动物罹患多种疾病。miRNA是一类内源性非编码单链RNA分子,在细胞的增殖与分化、自噬与凋亡、病毒感染等生理和病理过程中发挥重要作用。近年来相关研究发现,衣原体感染后能引起宿主的miRNA表达水平发生改变,其不仅调节宿主细胞线粒体网络结构进而影响衣原体的生长发育,还作为区分不同衣原体变体引起感染的早期生物标志物。miRNA参与了衣原体感染过程的调控,但miRNA在衣原体感染中的作用机制尚不完全清楚。本文就miRNA在衣原体感染中的作用进行简要综述。

Chlamydia is a type of obligate intracellular prokaryotic microorganisms. It is one of the most common pathogens, which cause a variety of diseases in humans and animals. Mi RNA is a group of endogenous non-coding single stranded RNAs, which plays a very important role in cell proliferation and differentiation, autophagy and apoptosis, and viral infection. In recent years, related studies have found that the expression model of miRNA was changed in Chlamydia infected host cells which indicates that miRNA may regulate Chlamydia infection process. Mi RNA not only regulates the mitochondrial netw...