期刊论文

Research progress of the relationship between α-ketoglutarate and atherosclerosis

中文

生命的化学

1000-1336

2018

38

1

25-29

10.13488/j.smhx.20180105

31670962:国家自然科学基金 81370378:国家自然科学基金 CX2017B551:湖南省研究生科研创新项目

本校为第一机构

α-酮戊二酸（α-ketoglutarate,α-KG）是戊二酸带酮基的衍生物中的一种,是三羧酸循环中重要的代谢中间产物,通过异柠檬酸脱氢酶（IDH）催化异柠檬酸氧化脱羧和谷氨酸脱氢酶催化谷氨酸氧化脱氨产生,是连接细胞内碳-氮代谢的关键节点。动脉粥样硬化（atherosclerosis,As）是一种慢性进行性疾病,病因复杂,且容易引发多种心脑血管疾病。本文从血管内皮细胞功能、自噬、DNA甲基化修饰、能量代谢、血管衰老等方面探讨α-KG与As之间的关系及其调控机制。

The molecule of α-ketoglutarate（α-KG） is a keto group derivative of glutaric acid. It is also an important metabolic intermediate in the tricarboxylic acid cycle, which is produced from isocitrate by oxidative decarboxylation and glutamate by oxidative deamination. It is a key node connecting the intracellular carbon-nitrogen metabolism. Atherosclerosis（As） is a chronic progressive disease, its pathogenesis is complex, and As can easily cause cardiovascular and cerebrovascular diseases. Recently, studies have showed that α-KG negatively ...