Calpain is a group of conservatives and specific calcium-dependent cysteine proteases, which is widely expressed in organisms. As one of the three major cell degradation systems, calpain plays a key role in cell proliferation, cytoskeleton remodeling, cell cycle regulation and apoptosis, glucose transport, cell signal transduction and other physiological processes. Many diseases are associated with calpain such as neurodegenerative diseases, muscular dystrophy, diabetes, cataracts, and tumors. As drugs, calpain-specific inhibitors or activators have been the focus on study. This review focuses...
