期刊论文

中文

生命的化学

1000-1336

2013

33

5

509-513

10.13488/j.smhx.2013.05.007

国家自然科学基金项目（81172119 31270894）

本校为第一机构

盐诱导激酶2(salt-inducible kinase 2, SIK2)是一种丝氨酸/苏氨酸蛋白激酶,属于AMP活化蛋白激酶(adenosine monophosphate-activated protein kinase, AMPK)亚家族成员之一。SIK2基因在脂肪组织中的表达水平最高,通过磷酸化负调节cAMP反应元件结合蛋白(cAMP-responsive element-binding protein,CREB)调节转录共激活子(CREB-regulated transcription co-activator, CRTC/TORC)2、3的活性;通过磷酸化p300/CBP,影响糖原异生和脂质合成相关基因的表达,在脂肪和糖代谢中发挥重要作用。另一方面,在营养缺乏等状态下,SIK2的Lys-53可被p300/CBP乙酰化暂时失去激酶活性并向胞浆中自吞噬体内聚集,在此被...

Salt-inducible kinase 2 （SIK2） is a serine/threonine protein kinase belonging to the member of AMP-activated protein kinase subfamily. The highest expression level of SIK2 gene was found in the fatty tissue. SIK2 phosphorylates the cAMP-responsive element-binding protein （CREB）-regulated transcription co-activator 2 and 3 （CRTC2; CRTC3）, and negatively regulates the transcription activity of these proteins. SIK2 can also phosphorylate the p300/CBP, which in turn modulates the expression of a series of genes related to gluconeogenesis and ...