The fabrication of hybrid micelles with enhanced permeability for drug delivery via a diethoxymethylsilyl-based crosslinking strategy

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成果类型：

期刊论文

作者：

Zhang, Xianshuo;Liu, Fangjun;Li, Xiaochen;Tian, Yunfei;Ma, Liwei;...

通讯作者：

Wei, Hua;Yu, Cuiyun

作者机构：

[Zhang, Xianshuo] Anyang Normal Univ, Sch Chem & Chem Engn, Anyang 455000, Henan, Peoples R China.

[Li, Xiaochen; Wei, Hua; Ma, Liwei; Zhang, Xianshuo; Liu, Fangjun; Tian, Yunfei] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

[Li, Xiaochen; Wei, Hua; Ma, Liwei; Zhang, Xianshuo; Liu, Fangjun; Tian, Yunfei] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Yu, Cuiyun; Wei, H] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Wei, Hua; Yu, Cuiyun; Wei, H] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Wei, Hua] L

[Yu, CY; Wei, H] U

Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

Polymer Chemistry

ISSN：

1759-9954

年：

2019

卷：

期：

页码：

4529-4536

DOI：

10.1039/c9py00810a

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51473072, 21504035]; Thousand Young Talents ProgramChinese Academy of Sciences; Outstanding Youth Fund of Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ1024]; National Basic Research Program of China (973 Program)National Basic Research Program of China [2018YFB1900201]; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Crosslinking based on triethoxysilyl-/ trimethoxysilyl functionality has been repeatedly highlighted to be the most frequently used strategy for producing crosslinked organic/ inorganic hybrid nanovehicles with enhanced stability for drug delivery applications. However, the permeability of the developed nanocarriers is another critical characteristic and should be simultaneously manipulated to realize sufficient release of the loaded therapeutic cargo in order to give an efficient therapeutic dose. The mainstream strategy to control the permeability of a hybrid nanocontainer is probably a modu...

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The fabrication of hybrid micelles with enhanced permeability for drug delivery via a diethoxymethylsilyl-based crosslinking strategy

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