Carboxyl terminal activating region 3 of latent membrane protein 1 encoded by the Epstein-Barr virus regulates cell proliferation and protein expression in NP69 cells

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成果类型：

期刊论文

作者：

Zhang, Zhi-Wei;Zhang, He-Liang;Yu, Yan-Hui;Ouyang, Yong-Mei;Chen, Zhu-Chu;...

通讯作者：

He, Xiu-Sheng;He, Zhi-Min

作者机构：

[Zhang, He-Liang; Zhang, Zhi-Wei; He, Xiu-Sheng] Univ South China, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan, Med Coll, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Ouyang, Yong-Mei; He, Zhi-Min; Zhang, Zhi-Wei; Yu, Yan-Hui; Chen, Zhu-Chu] Cent S Univ, Xiangya Sch Med, Canc Res Inst, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

[Zhang, He-Liang] Med Co, Troops 66028, Peoples Liberat Army, Chengde 067000, Hebei, Peoples R China.

[Chen, Zhu-Chu] Cent S Univ, Xiangya Hosp, Key Lab Canc Prote, Chinese Minist Hlth, Changsha 410078, Hunan, Peoples R China.

[He, Zhi-Min] Guangzhou Med Univ, Canc Res Inst, Guangzhou 510000, Guangdong, Peoples R China.

通讯机构：

[He, Xiu-Sheng] U

[He, Zhi-Min] C

Univ South China, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan, Med Coll, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Cent S Univ, Xiangya Sch Med, Canc Res Inst, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

latent membrane protein 1;carboxyl terminal activating region 3;NP69;cell proliferation;proteome;Janus kinase 3

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2020

卷：

期：

页码：

720-730

DOI：

10.3892/mmr.2019.10859

基金类别：

Hunan Provincial Innovation Foundation For Postgraduate; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30470668]; Health Department Scientific Research Foundation of Hunan Province [B2006-100]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

in the present study, the mechanism by which carboxyl terminal activating region 3 (cTar3) of latent membrane protein 1 (lMP1), encoded by the epstein-Barr virus, regulated cell proliferation and protein expression was investigated in the nasopharyngeal epithelial cell line nP69. The deletion mutant lMP1 (lMP1Δ232-351; amino acid residues including 232-351 codons in cTar3 deleted) was generated by polymerase chain reaction. an nP69-lMP1Δ232-351 cell line was established by retroviral infection. Finally, cell proliferation and protein expressi...

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Carboxyl terminal activating region 3 of latent membrane protein 1 encoded by the Epstein-Barr virus regulates cell proliferation and protein expression in NP69 cells

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