Identification and evaluation of the novel immunodominant antigen Rv2351c from Mycobacterium tuberculosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Xuezhi;Chen, Shuangshuang;Xu, Yongjuan;Zheng, Huajun;Xiao, Tongyang;...

通讯作者：

Wan, Kanglin

作者机构：

[Li, Yuqing; Chen, Shuangshuang; Chen, Xing; Liu, Haican; Xu, Yongjuan; Jiang, Yi; Wang, Xuezhi; Xiao, Tongyang; Li, Machao; Wan, Kanglin] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.

[Chen, Shuangshuang] Beijing Res Inst TB Control, Cent Lab, Beijing 100035, Peoples R China.

[Xu, Yongjuan] Huilongguan Community Hlth Serv Ctr, Prevent & Hlth Care, Beijing 100096, Peoples R China.

[Zheng, Huajun] Chinese Natl Human Genome Ctr Shanghai, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai 201203, Peoples R China.

[Li, Yuqing; Chen, Xing] Univ South China, Sch Publ Hlth, Epidemiol & Hlth Stat, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wan, Kanglin] C

Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.

语种：

英文

关键词：

cytokine;immunogenicity;Mycobacterium tuberculosis;Rv2351c;vaccine

期刊：

Emerging Microbes & Infections

ISSN：

2222-1751

年：

2017

卷：

期：

页码：

e48

DOI：

10.1038/emi.2017.34

基金类别：

National Key Program for Infectious Diseases of China [2013ZX10003006-002]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

There is an urgent need for new immunodominant antigens to improve the diagnosis of tuberculosis (TB) and the efficacy of the TB vaccine to control the disease worldwide. In this study, we evaluated the diagnostic potential of a novel Mycobacterium tuberculosis (MTB)-specific antigen, Rv2351c, from region of difference (RD) 7 of the MTB genome, and investigated the potency of the vaccine by identifying its immunological function in human and animal immunological experiments. Twenty T-cell epitopes were identified using TEpredict and prediction ...

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Identification and evaluation of the novel immunodominant antigen Rv2351c from Mycobacterium tuberculosis

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