Synthesis and anti-hepatocellular carcinoma evaluation of salicylic acid-modified indole trimethoxy flavonoid derivatives

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成果类型：

期刊论文

作者：

Zou, Yang;Lu, Na;Yang, Xiaoyan;Xie, Zhizhong;Lei, Xiaoyong;...

通讯作者：

Wang, Z;Tang, GT

作者机构：

[Wang, Zhe; Zou, Yang; Wang, Z] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong; Zou, Yang; Tang, Guotao] Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Hunan, Peoples R China.

[Lu, Na] Univ South China, Sch Nursing, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Li, Yong; Liu, Xingyun] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Huang, Sheng] Jiuzhitang Co Ltd, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Wang, Z ; Tang, GT ] U

Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

期刊：

RSC Medicinal Chemistry

ISSN：

2632-8682

年：

2023

卷：

期：

页码：

1172-1185

DOI：

10.1039/d3md00128h

基金类别：

Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research [2019-56]; Natural Science Foundation of Hunan Province [2020JJ4534]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

护理学院

摘要：

Simultaneous inhibition of tumor vasculature and the glycolysis pathway may be a targeted anti-tumor strategy to inhibit tumor nutrient supply. Flavonoids are natural products with strong biological activity, which inhibit hypoxia induction factor 1α (HIF-1α) regulating glycolysis and tumor angiogenesis, while salicylic acid can reduce the glycolysis level of tumor cells by inhibiting related rate-limiting enzymes. A series of salicylic acid-modified indole trimethoxy-flavone derivatives were designed and synthesized by introducing benzotrime...

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Synthesis and anti-hepatocellular carcinoma evaluation of salicylic acid-modified indole trimethoxy flavonoid derivatives

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