beta-catenin regulates IRF3-mediated innate immune signalling in colorectal cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ding, Chengming;He, Jun;Zhao, Jun;Li, Junhua;Chen, Jie;...

通讯作者：

Peng, Jian;Xia, Zanxian

作者机构：

[Jia, Zeming; Chen, Jie; Ding, Chengming; Zhang, Yaoting; Peng, Jian] Cent S Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Hunan, Peoples R China.

[He, Jun; Li, Chong; Ding, Chengming; Zhu, Zhu; Han, Dong] Univ South China, Dept Hepatopancreatobiliary Surg, Affiliated Hosp 1, Hengyang, Peoples R China.

[Li, Junhua; Ding, Chengming; Zhao, Jun] Univ Southern Calif, Dept Mol Microbiol & Immunol, Norris Comprehens Canc Ctr, Los Angeles, CA USA.

[Liao, Wenyan] Univ South China, Dept Obstet & Gynecol, Affiliated Hosp 1, Hengyang, Peoples R China.

[Zeng, Yi] Youjiang Med Univ Nationalities, Dept Pathol & Immunol, Baise, Peoples R China.

通讯机构：

[Peng, Jian; Xia, Zanxian] C

Cent S Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Hunan, Peoples R China.

Cent S Univ, State Key Lab Med Genet, Changsha, Hunan, Peoples R China.

Cent S Univ, Sch Life Sci, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

colorectal cancer;innate immunity;IRF3;RIG-I-like receptor (RLR)-mediated IFN-β signalling pathway;β-catenin

期刊：

Cell Proliferation

ISSN：

0960-7722

年：

2018

卷：

期：

页码：

e12464-

DOI：

10.1111/cpr.12464

基金类别：

the Joint Funds of the National Natural Science Foundation of China, Grant/Award Number: U1603126; Project of China Scholarship Council, Grant/Award Number: 201406370025; the National Key Research and Development Program of China, Grant/ Award Number: 2016YFC1200200 and 2016YFD0500300; Hunan Provincial Natural Science Fund, Grant/Award Number: (2018JJ3471) and 2017JJ2334;

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

AbstractObjectiveβ‐catenin is one of the most critical oncogenes associated with many kinds of human cancers, especially in the human CRC. Innate immunity recognizes tumour derived damage‐associated molecular patterns (DAMPs) and primes the anti‐tumour adaptive responses. While the function of β‐catenin in CRC tumourigenesis is well established, its impact on innate immune evasion is largely unknown. The aim of this study is to characterize the role of β‐catenin in inhibiting RIG‐I‐like receptor (RLR)‐mediated IFN‐β signalling in c...

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beta-catenin regulates IRF3-mediated innate immune signalling in colorectal cancer

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