期刊论文

Yi, Guang-Hui

英文

Lipids

0024-4201

2017

52

2

109-117

10.1007/s11745-016-4227-9

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270360, 31400652]; Scientific Research Fund of the Hunan Provincial Education DepartmentHunan Provincial Education Department [13C838]; Science and Technology Planning Project of the Hunan Provincial Science and Technology Department [2014FJ2012]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [14JJ2084]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]; Construct Program of the Key Discipline in Hunan Province, China (Basic Medicine Sciences of University of South China, Xiangjiaofa) [[2011]76]

本校为第一且通讯机构

Apolipoprotein M (apoM) is a relatively novel apolipoprotein that plays pivotal roles in many dyslipidemia-associated diseases; however, its regulatory mechanisms are poorly understood. Many cytokines have been identified that down-regulate apoM expression in HepG2 cells, among which transforming growth factor-β (TGF-β) exerts the most potent effects. In addition, c-Jun, a member of the activated protein 1 (AP-1) family whose activity is modulated by c-Jun N-terminal kinase (JNK), decreases apoM expression at the transcriptional level by bind...