版权说明 操作指南
首页 > 成果 > 详情

Hydrogen sulfide alleviates uranium-induced acute hepatotoxicity in rats: Role of antioxidant and antiapoptotic signaling

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Yuan, Yan;Zheng, Jifang;Zhao, Tingting;Tang, Xiaoqing;Hu, Nan
通讯作者:
Zheng, J.
作者机构:
Department of Biology, Institute of Biology, School of Pharmaceutical and Biological Science, University of South ChinaChangsheng West Road 28Hengyang City Hunan Province421001 People's Republic of China<&wdkj&>Department of Physiology, Institute of Neuroscience, Medical College, University of South ChinaChangsheng West Road 28Hengyang City Hunan Province421001 People's Republic of China<&wdkj&>Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and HydrometallurgyUniversity of South ChinaChangsheng West Road 28Hengyang City Hunan Province421001 People's Republic of China
[Zheng, Jifang; Yuan, Yan; Zhao, Tingting] Department of Biology, Institute of Biology, School of Pharmaceutical and Biological Science, University of South China, Changsheng West Road 28, Hengyang City, Hunan Province, 421001, People's Republic of China
[Tang, Xiaoqing] Department of Physiology, Institute of Neuroscience, Medical College, University of South China, Changsheng West Road 28, Hengyang City, Hunan Province, 421001, People's Republic of China
[Hu, Nan] Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Changsheng West Road 28, Hengyang City, Hunan Province, 421001, People's Republic of China
通讯机构:
[Zheng, Jifang] Univ South China, Sch Pharmaceut & Biol Sci, Inst Biol, Dept Biol, Changsheng West Rd 28, Hengyang City 421001, Hunan, Peoples R China.
语种:
英文
关键词:
hydrogen sulfide;uranium;hepatotoxicity;oxidative stress;apoptosis
期刊:
Environmental Toxicology
ISSN:
1520-4081
年:
2017
卷:
32
期:
2
页码:
581-593
基金类别:
Natural Science Foundation of Hunan Province [14JJ2087]; National Natural Science Foundation of China [81071005]; Zhengxiang Scholar Program of University of South China [2014-004]
机构署名:
本校为第一且通讯机构
院系归属:
核资源工程学院
医学院
药学与生物科学学院
摘要:
As an endogenous gaseous mediator, H<inf>2</inf>S exerts antioxidative, antiapoptotic, and cytoprotective effects in livers. This study was designed to investigate the protective role of H<inf>2</inf>S against uranium-induced hepatotoxicity in adult SD male rats after in vivo effect of uranium on endogenous H<inf>2</inf>S production was determined in livers. The levels of endogenous H<inf>2</inf>S and H<inf>2</inf>S-producing enzymes (CBS and CSE) were measured in liver homogenates from uranium -intoxicated rats. In rats injected intraperitoneally (i.p.) with uranyl acetate or NaHS (an H<inf>2</inf>S donor) alone or in combination, we examined biochemical parameters to assess liver function, revealed hepatic histopathological alteration, investigated oxidative stress markers, and explored apoptotic signaling in liver homogenates. The results suggest that uranium-intoxication in rats decreased CBS and CSE protein expression, H<inf>2</inf>S synthesis capacity, and endogenous H<inf>2</inf>S generation. NaHS administration in uranium-intoxicated rats produced amelioration in liver biochemical indices and histopathological effects, decreased MDA content, and increased GSH level and antioxidative enzymes activities like SOD, CAT, GPx, and GST. NaHS administration in uranium-intoxicated rats attenuated uranium-activated phosphorylation state of JNK. NaHS treatment in uranium-intoxicated rats increased antiapoptotic Bcl-2 but decreased pro-apoptotic Bax, resulting in the rise of Bcl-2/Bax ratio. NaHS treatment in uranium-intoxicated rats reduced the apoptosis mediator caspase-3 and cytochrome c release and elevated ATP contents. Taken together, these data implicate that H<inf>2</inf>S can afford protection to rat livers against uranium-induced adverse effects mediated by up-regulation of antioxidant and antiapoptotic signaling. The anti-apoptotic property of H<inf>2</inf>S may be involved, at least in part, in inhibiting JNK signaling. &copy;2016 Wiley Periodicals, Inc. Environ Toxicol 32: 581&ndash;593, 2017. &copy;2016 Wiley Periodicals, Inc.

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com