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Hydrogen sulfide alleviates uranium-induced acute hepatotoxicity in rats: Role of antioxidant and antiapoptotic signaling

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成果类型:
期刊论文
作者:
Yuan, Yan;Zheng, Jifang*;Zhao, Tingting;Tang, Xiaoqing;Hu, Nan
通讯作者:
Zheng, Jifang
作者机构:
[Zheng, Jifang; Yuan, Yan; Zhao, Tingting] Univ South China, Sch Pharmaceut & Biol Sci, Inst Biol, Dept Biol, Changsheng West Rd 28, Hengyang City 421001, Hunan, Peoples R China.
[Tang, Xiaoqing] Univ South China, Coll Med, Inst Neurosci, Dept Physiol, Changsheng West Rd 28, Hengyang City 421001, Hunan, Peoples R China.
[Hu, Nan] Univ South China, Key Discipline Lab Natl Def Biotechnol Uranium Mi, Changsheng West Rd 28, Hengyang City 421001, Hunan, Peoples R China.
通讯机构:
[Zheng, Jifang] U
Univ South China, Sch Pharmaceut & Biol Sci, Inst Biol, Dept Biol, Changsheng West Rd 28, Hengyang City 421001, Hunan, Peoples R China.
语种:
英文
关键词:
hydrogen sulfide;uranium;hepatotoxicity;oxidative stress;apoptosis
期刊:
Environmental Toxicology
ISSN:
1520-4081
年:
2017
卷:
32
期:
2
页码:
581-593
基金类别:
Contract grant sponsor: Contract grant sponsor: Natural Science Foundation of Hunan Province. Contract grant number: 14JJ2087 Contract grant sponsor: National Natural Science Foundation of China. Contract grant number: 81071005 Contract grant sponsor: Zhengxiang Scholar Program of University of South China. Contract grant number: 2014-004.
机构署名:
本校为第一且通讯机构
院系归属:
核资源工程学院
医学院
药学与生物科学学院
摘要:
As an endogenous gaseous mediator, H2S exerts antioxidative, antiapoptotic, and cytoprotective effects in livers. This study was designed to investigate the protective role of H2S against uranium-induced hepatotoxicity in adult SD male rats after in vivo effect of uranium on endogenous H2S production was determined in livers. The levels of endogenous H2S and H2S-producing enzymes (CBS and CSE) were measured in liver homogenates from uranium -intoxicated rats. In rats injected intraperitoneally (i.p.) with uranyl acetate or NaHS (an H2S donor) a...

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