Mechanistic insights into cardiovascular effects of ultrafine particle exposure: A longitudinal panel study

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成果类型：

期刊论文

作者：

Jiang, Yixuan;Zhu, Xinlei;Shen, Yang;He, Yu;Fan, Hao;...

通讯作者：

Kan, Haidong;Chen, RJ

作者机构：

[Zhu, Yixiang; Zhang, Qingli; Zhu, Xinlei; Xu, Xueyi; Liu, Cong; He, Yu; Du, Xihao; Kan, Haidong; Shen, Yang; Fan, Hao; Zhou, Lu; Cai, Jing; Xue, Xiaowei; Niu, Yue; Chen, Renjie; Jiang, Yixuan] Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Sch Publ Hlth, Shanghai, Peoples R China.

[Zhang, Lina] Zhejiang Chinese Med Univ, Sch Publ Hlth, Hangzhou, Zhejiang, Peoples R China.

[Zhang, Yang] Fudan Univ, Dept Syst Biol Med, Shanghai, Peoples R China.

[Zhang, Yang] Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Shanghai, Peoples R China.

[Kan, Haidong] Fudan Univ, Childrens Hosp, Natl Ctr Childrens Hlth, Shanghai, Peoples R China.

通讯机构：

[Kan, HD; Chen, RJ ] F

Fudan Univ, Sch Publ Hlth, Dept Environm Hlth, POB 249,130 Dong An Rd, Shanghai 200032, Peoples R China.

语种：

英文

关键词：

Ultrafine particle;Cardiovascular system;Panel study;Proteomics;Metabolomics

期刊：

Environment International

ISSN：

0160-4120

年：

2024

卷：

187

页码：

108714

DOI：

10.1016/j.envint.2024.108714

基金类别：

Science and Technology Commission of Shanghai Municipality [21TQ015]; National Key Research and Development Program [2022YFC3702701]; National Natural Science Foundation of China [82373532]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

BACKGROUND: Ultrafine particle (UFP) has been linked with higher risks of cardiovascular diseases; however, the biological mechanisms remain to be fully elucidated. OBJECTIVES: This study aims to investigate the cardiovascular responses to short-term UFP exposure and the biological pathways involved. METHODS: A longitudinal panel study was conducted among 32 healthy, non-smoking young adults in Shanghai, China, who were engaged in five rounds of follow-ups between December 2020 and November 2021. Individual exposures were calculated based on the indoor and outdoor real-time measurements. Blood...

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Mechanistic insights into cardiovascular effects of ultrafine particle exposure: A longitudinal panel study

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