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Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis

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成果类型:
期刊论文
作者:
Yin, Jie;Wu, Miaomiao;Duan, Jielin;Liu, Gang;Cui, Zhijie;Zheng, Jie;Chen, Shuai;Ren, Wenkai;Deng, Jinping;Tan, Xiangwen;Al-Dhabi, Naif Abdullah;Duraipandiyan, Veeramuthu;Liao, Peng;Li, Tiejun;Yin Yulong
通讯作者:
Liu, G.
作者机构:
Chinese Academy of Sciences<&wdkj&>University of Chinese Academy of Sciences<&wdkj&>Hunan Agricultural University<&wdkj&>University of South China<&wdkj&>King Saud University
[Yin, Jie; Duan, Jielin; Cui, Zhijie; Chen, Shuai; Ren, Wenkai; Al-Dhabi, Naif Abdullah; Duraipandiyan, Veeramuthu] Chinese Academy of Sciences
[Wu, Miaomiao; Liu, Gang; Zheng, Jie; Deng, Jinping] University of Chinese Academy of Sciences
[Tan, Xiangwen; Liao, Peng] Hunan Agricultural University
[Li, Tiejun] University of South China
通讯机构:
[Liu, Gang] Chinese Acad Sci, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Hunan Prov Engn Res Ctr Hlth Livestock,Minist Agr, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha 410125, Hunan, Peoples R China.
Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, China
语种:
英文
关键词:
PDTC;IBD;Antioxidant gene;Tight junction;NF-κB
期刊:
Applied Biochemistry and Biotechnology
ISSN:
0273-2289
年:
2015
卷:
177
期:
8
页码:
1716-1728
基金类别:
National Natural Science Foundation of China [31272463]; Hunan Provincial Natural Science Foundation [12JJ2014, 13JJ2034]; China Scholarship Council; King Saud University, Deanship Scientific Research, College of Science, Research Center
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Inflammatory bowel disease (IBD) correlates with oxidative stress, inflammation, and alteration in several signal pathways, including nuclear transcription factor-kappaB (NF-&kappa;B). Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-&kappa;B, has been widely demonstrated to exhibit an antioxidant and anti-inflammatory function. This study aimed to test the hypothesis that NF-&kappa;B inhibitor PDTC confers a beneficial role in a colitis model induced by dextran sodium sulfate (DSS) in mouse. The results showed that DSS decreased daily weight gain, induced colonic inflammation, suppressed the expression of antioxidant enzymes and tight junctions, and activated NF-&kappa;B and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling pathways. PDTC significantly upregulated (P&nbsp;&lt;&nbsp;0.05) Gpx1, Gpx4, occludin, and ZO-1 expressions in the DSS-induced colitis model. Meanwhile, PDTC reversed (P&nbsp;&lt;&nbsp;0.05) the activation of NF-&kappa;B signal pathway caused by DSS treatment. In conclusion, PDTC could serve as an adjuvant therapy for the patient with IBD. &copy;2015, Springer Science+Business Media New York.

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