Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis

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成果类型：

期刊论文

作者：

Yin, Jie;Wu, Miaomiao;Duan, Jielin;Liu, Gang*;Cui, Zhijie;...

通讯作者：

Liu, Gang

作者机构：

[Liu, Gang; Cui, Zhijie; Chen, Shuai; Li, Tiejun; Liao, Peng; Yin, Jie; Ren, Wenkai; Wu, Miaomiao; Duan, Jielin; Yin Yulong] Chinese Acad Sci, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Hunan Prov Engn Res Ctr Hlth Livestock,Minist Agr, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha 410125, Hunan, Peoples R China.

[Cui, Zhijie; Yin, Jie; Wu, Miaomiao; Duan, Jielin] Univ Chinese Acad Sci, Beijing 100039, Peoples R China.

[Zheng, Jie; Deng, Jinping] Hunan Agr Univ, Coll Anim Sci, Changsha 410128, Hunan, Peoples R China.

[Tan, Xiangwen] Univ South China, Dept Lab Anim Sci, Hengyang 421001, Peoples R China.

[Duraipandiyan, Veeramuthu; Al-Dhabi, Naif Abdullah] King Saud Univ, Coll Sci, Addiriyah Chair Environm Studies, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia.

通讯机构：

[Liu, Gang] C

Chinese Acad Sci, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Hunan Prov Engn Res Ctr Hlth Livestock,Minist Agr, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

Antioxidant gene;IBD;NF-kappaB;PDTC;Tight junction

期刊：

Applied Biochemistry and Biotechnology

ISSN：

0273-2289

年：

2015

卷：

177

期：

页码：

1716-1728

DOI：

10.1007/s12010-015-1848-z

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31272463]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [12JJ2014, 13JJ2034]; China Scholarship CouncilChina Scholarship Council; King Saud University, Deanship Scientific Research, College of Science, Research Center

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Inflammatory bowel disease (IBD) correlates with oxidative stress, inflammation, and alteration in several signal pathways, including nuclear transcription factor-kappaB (NF-κB). Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB, has been widely demonstrated to exhibit an antioxidant and anti-inflammatory function. This study aimed to test the hypothesis that NF-κB inhibitor PDTC confers a beneficial role in a colitis model induced by dextran sodium sulfate (DSS) in mouse. The results showed that DSS decreased daily weight gain, induced colonic inflammation, suppresse...

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Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis

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