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Curcumin-Mediated Induction of Apoptosis in Human Glioma CHME Cells

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成果类型:
期刊论文
作者:
Zhang, Yunqiang;Tu, Lijun;Zhou, Xiuhong;Li, Bin
作者机构:
[Li, Bin; Zhang, Yunqiang] Department of Neurosurgery, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China (mainland)
[Tu, Lijun] Electrocardiographic Room, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China (mainland)
[Zhou, Xiuhong] Department of Pathophysiology, University of South China, Hengyang, Hunan, China (mainland)
语种:
英文
关键词:
CASP3 protein, human;CASP9 protein, human;caspase 3;caspase 9;curcumin;reactive oxygen metabolite;apoptosis;cell proliferation;cell survival;drug effect;glioma;human;metabolism;mitochondrion;pathology;signal transduction;tumor cell line;Apoptosis;Caspase 3;Caspase 9;Cell Line, Tumor;Cell Proliferation;Cell Survival;Curcumin;Glioma;Humans;Mitochondria;Reactive Oxygen Species;Signal Transduction
期刊:
Medical science monitor basic research
ISSN:
2325-4394
年:
2018
卷:
24
页码:
216-224
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
BACKGROUND Curcumin has clear anti-tumor activity in various carcinomas. It regulates various signaling pathways like Wnt/β-catenin and JAK2/STAT3, which play vital roles in cell proliferation of several carcinomas, but to the best of our knowledge, there are currently no published reports on human glioma CHME cells. Therefore, the aim of this study was to explore the effect of curcumin on human glioma CHME cells. MATERIAL AND METHODS The CHME cell line was purchased from American Type Culture Collection (ATCC). The expressions of caspases 3, ...

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