Identification of the C-terminal domain of Daxx acts as a potential regulator of intracellular cholesterol synthesis in HepG2 cells

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成果类型：

期刊论文

作者：

Sun, Shaowei;Wen, Juan;Qiu, Fei;Yin, Yufang;Xu, Guina;...

通讯作者：

Chen, Jianxiong;Tuo, Qinhui

作者机构：

[Xu, Guina; Sun, Shaowei; Wen, Juan; Xiong, Guozuo; Li, Tianping; Zhang, Caiping] Univ South China, Inst Pharm & Pharmacol, Sch Life Sci & Technol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Jianxiong; Sun, Shaowei; Qiu, Fei; Chen, JX; Tuo, Qinhui; Nie, Juan; Liao, Duangfang] Hunan Univ Chinese Med, Sch Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Yin, Yufang] Southern Illinois Univ, Dept Pharmacol, Sch Med, Springfield, IL 62702 USA.

[Chen, Jianxiong] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.

通讯机构：

[Chen, JX; Tuo, QH] H

Hunan Univ Chinese Med, Sch Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

*Androgen receptor;*Cholesterol;*Fas death domain-associated protein;*SCAP;*SREBP

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2016

卷：

480

期：

页码：

139-145

DOI：

10.1016/j.bbrc.2016.09.102

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30971267, 81673722, 81670268, 81600291]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ3109, 2015JJ2117]; Key projects of Hunan Provincial Department of Education [16A156]; Hunan Province National Funds for Distinguished Young Scientists [14JJ1024]; One Hundred Talent Program of Human Province

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Daxx is a highly conserved nuclear transcriptional factor, which has been implicated in many nuclear processes including transcription and cell cycle regulation. Our previous study demonstrated Daxx also plays a role in regulation of intracellular cholesterol content. Daxx contains several domains that are essential for interaction with a growing number of proteins. To delineate the underlying mechanism of hypocholesterolemic activity of Daxx, we constructed a set of plasmids which can be used to overexpress different fragments of Daxx and tran...

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Identification of the C-terminal domain of Daxx acts as a potential regulator of intracellular cholesterol synthesis in HepG2 cells

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