Identification of the C-terminal domain of Daxx acts as a potential regulator of intracellular cholesterol synthesis in HepG2 cells

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期刊论文

作者：

Sun, Shaowei;Wen, Juan;Qiu, Fei;Yin, Yufang;Xu, Guina;...

通讯作者：

Chen, Jianxiong;Tuo, QH

作者机构：

[Xu, Guina; Sun, Shaowei; Wen, Juan; Xiong, Guozuo; Li, Tianping; Zhang, Caiping] Univ South China, Inst Pharm & Pharmacol, Sch Life Sci & Technol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Jianxiong; Chen, JX; Sun, Shaowei; Tuo, Qinhui; Qiu, Fei; Nie, Juan; Liao, Duangfang] Hunan Univ Chinese Med, Sch Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Yin, Yufang] Southern Illinois Univ, Dept Pharmacol, Sch Med, Springfield, IL 62702 USA.

[Chen, Jianxiong] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.

通讯机构：

[Chen, JX; Tuo, QH ] H

Hunan Univ Chinese Med, Sch Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

*Androgen receptor;*Cholesterol;*Fas death domain-associated protein;*SCAP;*SREBP

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2016

卷：

480

期：

页码：

139-145

DOI：

10.1016/j.bbrc.2016.09.102

基金类别：

This work was supported by grants from the National Natural Science Foundation of China ( 30971267 , 81673722 , 81670268 and 81600291 ), Natural Science Foundation of Hunan Province ( 2016JJ3109 , 2015JJ2117 ), Key projects of Hunan Provincial Department of Education ( 16A156 ), Hunan Province National Funds for Distinguished Young Scientists ( 14JJ1024 ) and One Hundred Talent Program of Human Province (JX Chen).

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Daxx is a highly conserved nuclear transcriptional factor, which has been implicated in many nuclear processes including transcription and cell cycle regulation. Our previous study demonstrated Daxx also plays a role in regulation of intracellular cholesterol content. Daxx contains several domains that are essential for interaction with a growing number of proteins. To delineate the underlying mechanism of hypocholesterolemic activity of Daxx, we constructed a set of plasmids which can be used to overexpress different fragments of Daxx and transfected to HepG2 cells. We found that the C-termin...

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Identification of the C-terminal domain of Daxx acts as a potential regulator of intracellular cholesterol synthesis in HepG2 cells

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