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Autophagy Is Essential for Neural Stem Cell Proliferation Promoted by Hypoxia

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成果类型:
期刊论文
作者:
Li, Jian;Gong, Sheng-Hui;He, Yun-Ling;Cao, Yan;Chen, Ying;...
通讯作者:
Hai-Tao Wu<&wdkj&>Ling-Ling Zhu<&wdkj&>Li-Ying Wu
作者机构:
[Chen, Ying; Wang, Yu-Fei; Cao, Yan; Wu, Li-Ying; Li, Jian] Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 100850, Peoples R China.
[Zhou, Yan-Zhao; Zhao, Tong; Zhao, Ming; Wu, Hai-Tao; Cheng, Xiang; Fan, Ming; Zhu, Ling-Ling; Zhao, Yong-Qi; He, Yun-Ling; Wu, Li-Ying; Gong, Sheng-Hui; Huang, Guang-Hai] Beijing Inst Basic Med Sci, Dept Neurobiol, Beijing, Peoples R China.
[Zhu, Ling-Ling] Nantong Univ, Coinnovat Ctr Neuroregenerat, Dept Neuroregenerat, Nantong, Peoples R China.
[Zhu, Ling-Ling] Univ Nanhua, Dept Pharmacol, Hengyang 421000, Peoples R China.
通讯机构:
[Hai-Tao Wu; Ling-Ling Zhu] D
[Li-Ying Wu] S
Department of Neurobiology, Beijing Institute of Basic Medical Sciences , Beijing , People’s Republic of China<&wdkj&>Department of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University , Nantong , People’s Republic of China<&wdkj&>Department of Pharmacology, University of Nanhua , Hengyang , China<&wdkj&>State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , Beijing , People’s Republic of China<&wdkj&>Department of Neurobiology, Beijing Institute of Basic Medical Sciences , Beijing , People’s Republic of China<&wdkj&>Department of Neurobiology, Beijing Institute of Basic Medical Sciences , Beijing , People’s Republic of China
语种:
英文
关键词:
autophagy;neural stem cells;hypoxia;proliferation;HIF-1;mTORC1
期刊:
Natural Immunity
ISSN:
1018-8916
年:
2023
卷:
41
期:
1
页码:
77-92
基金类别:
National Natural Science Foundation of China [31271211, 31771321, 81971781, 32171148]; Key Program of National Nature Sciences Foundation of China [81430044]; National Key Research and Development Program of China [2021YFA1101800, 2021ZD0202500, 2021YFA1101801]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Hypoxia as a microenvironment or niche stimulates proliferation of neural stem cells (NSCs). However, the underlying mechanisms remain elusive. Autophagy is a protective mechanism by which recycled cellular components and energy are rapidly supplied to the cell under stress. Whether autophagy mediates the proliferation of NSCs under hypoxia and how hypoxia induces autophagy remain unclear. Here, we report that hypoxia facilitates embryonic NSC proliferation through HIF-1/mTORC1 signaling pathway-mediated autophagy. Initially, we found that hypoxia greatly induced autophagy in NSCs, while inhib...

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