期刊论文

Yao, Xu;Mi, Pengbing;Zheng, X

英文

Medicinal Chemistry Research

1054-2523

2023

32

11

2279-2298

10.1007/s00044-023-03147-2

Laboratory of Tea and Health of Heng-yang [202150083704]; Undergraduate Research Learning and Innovative Experiment Project [X202110555454, X202110555467, X202110555473, 220XCX105, 220XCX310, 220XCX294]; Undergraduate scientific Research Innovation Project of University of South China [S202110555253, 202110555063]

本校为第一且通讯机构

As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic triterpenoid with significant anti-lung cancer activity and low toxicity. The bottleneck of UA in clinical application is poor water solubility and bioavailability. Until now, many novel UA derivatives have been developed to overtake these problems. In this paper, the relationship between the structure and activity of different functional groups was discussed. All anti-lung cancer ursolic acid derivatives were reviewed, and their biological activity and stru...