Evaluation of FlaB1, FlaB2, FlaB3, and Tp0463 of Treponema pallidum for serodiagnosis of syphilis

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成果类型：

期刊论文

作者：

Jiang, Chuanhao;Xiao, Jinhong;Xie, Yafeng;Xiao, Yongjian;Wang, Chuan;...

通讯作者：

Wu, Yimou

作者机构：

[Wu, Yimou; Zhao, Feijun; Kuang, Xingxing; Xu, Man; Zeng, Tiebing; Jiang, Chuanhao; Xie, Yafeng; Li, Ranhui; Wang, Chuan] Univ South China, Pathogen Biol Inst, Hunan Prov Key Lab Special Pathogens Prevent & Co, Coll Med, Hengyang 421001, Peoples R China.

[Xiao, Jinhong] Hunan Prov Peoples Hosp, Clin Lab, Changsha 410005, Hunan, Peoples R China.

[Xiao, Yongjian] Univ South China, Affiliated Hosp 2, Clin Lab, Hengyang 421001, Peoples R China.

[Liu, Shuanquan] Univ South China, Affiliated Hosp 1, Clin Lab, Hengyang 421001, Peoples R China.

[Yu, Jian] Univ South China, Coll Med, Dept Expt Zool, Hengyang 421001, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Pathogen Biol Inst, Hunan Prov Key Lab Special Pathogens Prevent & Co, Coll Med, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Treponema pallidum;Syphilis;Congenital syphilis;Flagellin;Recombinant protein

期刊：

Diagnostic Microbiology and Infectious Disease

ISSN：

0732-8893

年：

2016

卷：

期：

页码：

105-111

DOI：

10.1016/j.diagmicrobio.2015.10.005

基金类别：

This work was supported by the National Natural Science Foundation of China (grant nos. 81471576 , 30800996 , 81373230 , and 81201331 ), the Construct Program of the Key Discipline in Hunan Province ( 2011-76 ), and Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (grant nos. 2014-5 and 2012-312 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Syphilis is a multistage disease caused by the invasive spirochete Treponema pallidum subsp. pallidum, and accurate diagnosis is important for the prevention and treatment of syphilis. Here, to identify appropriate diagnostic antigens for serodiagnosis of syphilis, 6 recombinant proteins were expressed in Escherichia coli and purified, including flagellins (FlaB1 [Tp08681, FlaB2 [Tp0792], and FlaB3 [Tp0870]), Tp0463, Tp0751, and Tp1038. The sensitivities were determined by screening sera from individuals with primary (n = 82), secondary (n = 115), latent (n = 105), and congenital (n = 65) syph...

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Evaluation of FlaB1, FlaB2, FlaB3, and Tp0463 of Treponema pallidum for serodiagnosis of syphilis

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