Blood pressure reducing effects of piromelatine and melatonin in spontaneously hypertensive rats.

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成果类型：

期刊论文

作者：

Huang, L.;Zhang, C.;Hou, Y.;Laudon, M.;She, M.;...

通讯作者：

Yin, W.

作者机构：

[Zhang, C.; Yin, W.; Hou, Y.; Huang, L.; He, P.] Univ South China, Key Lab Arteriosclerosis Hunan Prov, Inst Cardiovasc Res, Hengyang, Hunan, Peoples R China.

[Huang, L.; Wang, H.] Univ South China, Dept Operat Surg, Hengyang, Hunan, Peoples R China.

[Yin, W.; She, M.; Ding, L.; Yang, S.] Univ South China, Dept Biochem & Mol Biol, Sch Life Sci & Technol, Hengyang, Hunan, Peoples R China.

[Laudon, M.] Neurim Pharmaceut Ltd, Drug Discovery, Tel Aviv, Israel.

[Wang, Z.] Univ South China, Dept Lab Anim Sci, Hengyang, Hunan, Peoples R China.

通讯机构：

[Yin, W.] U

Univ South China, Key Lab Arteriosclerosis Hunan Prov, Inst Cardiovasc Res, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Piromelatine;Melatonin;Hypertension;Spontaneously hypertensive rats;Metabolic diseases

期刊：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES

ISSN：

1128-3602

年：

2013

卷：

期：

页码：

2449-2456

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100106, 81200590]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [11C1093, 11C1095]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Recently, widespread interest has grown regarding melatonin treatment of hypertension including its cardioprotective effects. Studies in rodents indicate that melatonin plays a role in the pathogenesis of hypertension in rats with metabolic syndrome. Piromelatine, a melatonin agonist, serotonin 5-HT-1A and 5-HT-1D agonist and serotonin 5-HT2B antagonist is a multimodal agent with sleep promoting, anti-diabetic, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potential, currently in development for the treatment of insomnia. In this report we assessed the effects of piromelatin...

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Blood pressure reducing effects of piromelatine and melatonin in spontaneously hypertensive rats.

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