版权说明 操作指南
首页 > 成果 > 详情

Synthesis, structure, and in vitro antiproliferative activity of cyclic hypervalent organobismuth(III) chlorides and their triphenylgermylpropionate derivatives

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Zhang, Xiao-Wen;Xia, Jun;Yan, Hui-Wen;Luo, Sheng-Lian;Yin, Shuang-Feng;Au, Chak-Tong;Wong, Wai-Yeung
通讯作者:
Yin, S.-F.
作者机构:
[Xia, Jun; Luo, Sheng-Lian; Au, Chak-Tong; Yin, Shuang-Feng; Zhang, Xiao-Wen] College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China
[Zhang, Xiao-Wen] Key Laboratory of Pollution Control and Resource Use of Hunan Province, University of South China, Hengyang, 421001, China
[Yan, Hui-Wen] Cell Biology of Bioscience, Technology Academy, Central South University, Changsha, 410013, China
[Au, Chak-Tong] Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Hong Kong
[Wong, Wai-Yeung] Department of Chemistry, Centre for Advanced Luminescence Materials, Hong Kong Baptist University, Kowloon Tong, Hong Kong, Hong Kong
通讯机构:
[Yin, Shuang-Feng] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Peoples R China.
College of Chemistry and Chemical Engineering, Hunan University, China
语种:
英文
关键词:
Antiproliferative activity;Bismuth;Germanium;Hypervalent
期刊:
Journal of Organometallic Chemistry
ISSN:
0022-328X
年:
2009
卷:
694
期:
18
页码:
3019-3026
机构署名:
本校为其他机构
院系归属:
土木工程学院
摘要:
Six compounds of cyclic hypervalent organobismuth(III) chlorides and triphenylgermylpropionates bearing a nitrogen or sulfur atom as intramolecular coordination atom have been synthesized and characterized. The results of single-crystal X-ray analysis reveal that the eight-membered tetrahydroazabismocine rings are highly flexible. The Bi-S or Bi-N bond lengths in the thiabismocine or azabismocine derivatives are dependent on how the substituted groups are acting on the Bi, S or N atom. The replacement of the chlorine atom in azabismocine and thiabismocine with the triphenylgermylpropionic group (Ph<inf>3</inf>GeCH<inf>2</inf>CH<inf>2</inf>COO{single bond}) leads to the lengthening of Bi-N and Bi-S bond. The substituents connected with the nitrogen atom also have an effect on the Bi-N bond length of azabismocine. For example, a cyclohexyl group has electron-donating ability higher than a phenyl group;the replacement of the former by the latter would lead to the decline of Bi-N bond length and increase of C<inf>Ar</inf>-Bi-C<inf>Ar</inf> angle in the eight-membered ring. The in vitro antiproliferative activities of the fabricated materials were compared on gastric carcinoma cells by means of the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide (MTT) method. It was found that the compounds show antiproliferative activity on gastric carcinoma cells (MGC-803) much higher than that of cisplatin. Moreover, there is enhancement of antiproliferative activity when the chlorine atom of the bismocine compounds is replaced by the triphenylgermylpropionic group, giving a low IC<inf>50</inf> value of 0.7 &mu;M for thiabismocine triphenylgermylpropionate. &copy;2009 Elsevier B.V. All rights reserved.

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com