Multicenter Research on the BACTEC MGIT 960 system for the second-line drugs susceptibility testing of Mycobacterium tuberculosis in China

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成果类型：

期刊论文

作者：

Zhao, Li-li;Liang, Ya-ping;Huang, Ming-xiang;Tan, Yun-hong;Jiang, Yuan;...

通讯作者：

Wan, Kang-lin

作者机构：

[Zhao, Li-li; Liu, Zhiguang; Jiang, Yi; Chen, Yan; Wan, Kang-lin] Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Reference Lab TB, Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China.

[Gao, Man; Liang, Ya-ping] Shaanxi TB Prevent & Treatment Hosp, Xian 710100, Peoples R China.

[Huang, Ming-xiang] Fujian Med Univ, Clin Teaching Hosp, Fuzhou Pulm Hosp, Fuzhou 350008, Peoples R China.

[Chen, Zhongnan; Tan, Yun-hong] Hunan Inst TB Control, Changsha 410013, Hunan, Peoples R China.

[Wu, Jie; Jiang, Yuan] Shanghai Municipal Ctr Dis Control & Prevent, Dept TB Prevent & Control, Shanghai 200336, Peoples R China.

通讯机构：

[Wan, Kang-lin] C

Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Reference Lab TB, Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China.

语种：

英文

关键词：

BACTEC MGIT 960 system;Drug susceptibility testing;Lowenstein-Jensen proportion method;Multicenter research;Mycobacterium tuberculosis;The second-line drugs

期刊：

Diagnostic Microbiology and Infectious Disease

ISSN：

0732-8893

年：

2013

卷：

期：

页码：

330-334

DOI：

10.1016/j.diagmicrobio.2013.08.028

基金类别：

We thank Professor Salman Siddiqi (Becton Dickinson Diagnostic Systems, Sparks, MD, USA) and Eric Zhao (Becton Dickinson Diagnostic Systems, Beijing, China) for helpful advice on the experiments; the staff of Fujian, Hunan, Shaanxi, Shanghai, and Liaoning for their excellent work. This work is financially supported by the Collaboration Project for Tuberculosis Control Managed between the International Health Exchange and Cooperation Center, Ministry of Health of the People's Republic of China and Becton Dickinson Medical Devices (Shanghai).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The reliability of the BACTEC MGIT 960 system for the second-line drugs (capreomycin [CPM], kanamycin [KAN], ofloxacin [OFX] and ethionamide [ETH]) susceptibility testing (DST) of Mycobacterium tuberculosis (M. tuberculosis) was compared to that of traditional Lowenstein-Jensen (L-J) proportion method (PM) among four different sites in China. After resolution of discrepant results by retesting the strains using both methods in the National Reference Laboratory of tuberculosis, the overall concordance values between the 2 systems were 99.7% (kap...

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