Tailored multilayer nanoparticles against resistant P. aeruginosa by disrupting the thickened mucus, dense biofilm and hyperinflammation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xu, Mao;Yu, Shihui*;Li, Pengyu;Chen, Yili;Chen, Yujun;...

通讯作者：

Yu, Shihui;Hu, HY;Deng, X

作者机构：

[Pan, Jieyi; Yu, Shihui; Hu, Haiyan; Chen, Yujun; Li, Pengyu; Xu, Mao] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.

[Hu, Haiyan] Sun Yat Sen Univ, Sch Pharmaceut Sci, State Key Lab Antiinfect Drug Discovery & Dev, Guangzhou 510006, Peoples R China.

[Hu, Haiyan] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China.

[Li, Pengyu] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Pharm, Changsha 410004, Peoples R China.

[Chen, Yili] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Peoples R China.

通讯机构：

[Yu, SH; Hu, HY ] S

[Deng, X ] C

Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.

Sun Yat Sen Univ, Sch Pharmaceut Sci, State Key Lab Antiinfect Drug Discovery & Dev, Guangzhou 510006, Peoples R China.

Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China.

语种：

英文

关键词：

Dense biofilm;Excessive inflammation;MDRP. aeruginosa biofilms;N-acetylcysteine-ε-poly-l-lysine;Tailored multilayer nanoparticles;Thickened mucus;Vanillin-chitosan

期刊：

Journal of Controlled Release

ISSN：

0168-3659

年：

2025

卷：

378

页码：

588-604

DOI：

10.1016/j.jconrel.2024.12.040

基金类别：

CRediT authorship contribution statement Mao Xu: Writing – original draft, Methodology, Data curation, Conceptualization. Shihui Yu: Writing – review & editing, Writing – original draft, Project administration, Conceptualization. Pengyu Li: Writing – review & editing, Conceptualization. Yili Chen: Resources, Investigation. Yujun Chen: Investigation, Data curation. Jieyi Pan: Visualization, Investigation, Data curation. Xin Deng: Supervision, Conceptualization. Haiyan Hu: Supervision, Project administration, acquisition,

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Therapeutic challenges of chronic pulmonary infections caused by multidrug-resistant Pseudomonas aeruginosa (MDR P. aeruginosa ) biofilms due to significantly enhanced antibiotic resistance. This resistance is driven by reduced outer membrane permeability, biofilm barriers, and excessive secretion of virulence factors. Thickened mucus in the airways exacerbates the problem by impeding antibiotic penetration, providing a breeding ground for biofilms, consequently aggravating infection. Moreover, biofilms recruit numerous immune cells, resulting ...

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Tailored multilayer nanoparticles against resistant P. aeruginosa by disrupting the thickened mucus, dense biofilm and hyperinflammation

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