SUMOylation targeting mitophagy in cardiovascular diseases

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiao, Hong;Zhou, Hong;Zeng, Gaofeng;Mao, Zhenjiang;Zeng, Junfa;...

通讯作者：

Junfa Zeng<&wdkj&>Anbo Gao

作者机构：

[Xiao, Hong; Zeng, Junfa] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Crit Care Med, Hengyang 421002, Hunan, Peoples R China.

[Zhou, Hong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Radiol, Hengyang 421002, Hunan, Peoples R China.

[Zeng, Gaofeng] Univ South China, Affiliated Hosp 2, Hengyang Med Sch,Key Lab Heart Failure Prevent &, Dept Cardiovasc Med,Clin Med Res Ctr Arterioscler, Hengyang 421002, Hunan, Peoples R China.

[Mao, Zhenjiang] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Gastroenterol, Hengyang 421002, Hunan, Peoples R China.

[Gao, Anbo] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Clin Res Inst, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Junfa Zeng] D

[Anbo Gao] C

Department of Critical Care Medicine, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hunan, China<&wdkj&>Clinical Research Institute, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hunan, China

语种：

英文

关键词：

SUMO;SUMOylation;Mitochondria;Mitophagy;Cardiovascular diseases

期刊：

Journal of Molecular Medicine

ISSN：

0946-2716

年：

2022

卷：

100

期：

页码：

1511-1538

DOI：

10.1007/s00109-022-02258-4

基金类别：

This work is supported by grants from the Scientific Research Project of Hunan Provincial Health Commission of China (No. 202203013975), the Natural Science Foundation of Hunan Province (2022JJ40386), the Ph.D. Research Start-up Fund of the Second Affiliated Hospital of Hengyang Medical College of University of South China (No. 2021B02), and the scientific research project of Hunan Provincial Department of Education (No. 21B0407).

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Small ubiquitin-like modifier (SUMO) plays a key regulatory role in cardiovascular diseases, such as cardiac hypertrophy, hypertension, atherosclerosis, and cardiac ischemia-reperfusion injury. As a multifunctional posttranslational modification molecule in eukaryotic cells, SUMOylation is essentially associated with the regulation of mitochondrial dynamics, especially mitophagy, which is involved in the progression and development of cardiovascular diseases. SUMOylation targeting mitochondrial-associated proteins is admittedly considered to re...

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SUMOylation targeting mitophagy in cardiovascular diseases

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