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Vaccination with MIP or Pgp3 induces cross-serovar protection against chlamydial genital tract infection in mice

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成果类型:
期刊论文
作者:
Luan, Xiuli;Peng, Bo;Li, Zhongyu;Tang, Lingli;Chen, Chaoqun;...
通讯作者:
Lu, Chunxue
作者机构:
[Li, Zhongyu; Lu, Chunxue; Peng, Bo; Chen, Chaoqun; Chen, Lili; Luan, Xiuli; Wu, Haiying; Sun, Zhenjie] Univ South China, Hengyang Med Coll, Pathogen Biol Inst, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.
[Li, Zhongyu; Lu, Chunxue; Peng, Bo; Luan, Xiuli] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
[Peng, Bo] Univ South China, Hengyang Med Coll, Dept Pathol, Hengyang 421001, Peoples R China.
[Tang, Lingli] Cent S Univ, Xiangya Hosp 2, Dept Clin Diag, Changsha 410011, Hunan, Peoples R China.
[Lu, Chunxue] Univ South China, Pathogen Biol Inst, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Lu, Chunxue] U
Univ South China, Pathogen Biol Inst, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
*Chlamydia trachomatis;*Cross-serovar protection;*MIP;*Pgp3;*Vaccination
期刊:
Immunobiology
ISSN:
0171-2985
年:
2019
卷:
224
期:
2
页码:
223-230
基金类别:
This project was supported by the Natural Science Foundation of China ( 81471969 , 81202374 & 31600150 ), the construct program of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (Grant No. 2014-5 ), and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Grant No. 2015-351 ).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Previously we reported that recombinant Chlamydia muridarum macrophage infectivity potentiator (MIP) provided partial protection against C. muridarum genital tract infection in mice. On the other hand, Chlamydia trachomatis plasmid encoded Pgp3could induce the protection against C. muridarum air way infection. This study aimed to evaluate the immunogenicity of MIP and Pgp3 from C. trachomatis serovar D and further investigate whether MIP and Pgp3 provide cross-serovar protection against C. muridarum genital tract infection in mice. Our results ...

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