Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats

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成果类型：

期刊论文

作者：

Qin, Xu-Ping*;Zeng, Si-Yu;Tian, Hai-Hong;Deng, Shui-Xiu;Ren, Jun-Fang;...

通讯作者：

Qin, Xu-Ping

作者机构：

[Deng, Shui-Xiu; Tian, Hai-Hong; Zheng, Yuan-Bin; Zeng, Si-Yu; Ren, Jun-Fang; Liao, Duan-Fang; Qin, Xu-Ping] Univ S China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Li, Dai; Li, Yuan-Jian] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha, Hunan, Peoples R China.

[Chen, Shi-You] Univ Georgia, Coll Vet Med, Dept Physiol & Pharmacol, Athens, GA 30602 USA.

[Qin, Xu-Ping] Fourth Hosp Changsha, Changsha, Hunan, Peoples R China.

通讯机构：

[Qin, Xu-Ping] F

Fourth Hosp Changsha, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

prolylcarboxypeptidase;rat;renohypertension;rutaecarpine;vascular remodelling

期刊：

Clinical and Experimental Pharmacology and Physiology

ISSN：

0305-1870

年：

2009

卷：

期：

页码：

319-324

DOI：

10.1111/j.1440-1681.2008.05079.x

基金类别：

National Nature Science Foundation of China [30572192, 30430740]; American Heart Association [0765265U]; National Institutes of Health [1R01HL093429-01]

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Previous studies indicate that rutaecarpine blocks increases in blood pressure and inhibits vascular hypertrophy in experimentally hypertensive rats. The aim of the present study was to determine whether the effects of rutaecarpine are related to activation of prolylcarboxypeptidase (PRCP). Renovascular hypertensive rats (Goldblatt two-kidney, one-clip (2K1C)) were developed using male Sprague-Dawley rats. Chronic treatment with rutaecarpine (10 or 40 mg/kg per day) or losartan (20 mg/kg per day) for 4 weeks to the hypertensive rats caused a su...

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Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats

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