The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lv, Xiu;Li, Jincheng;Zhang, Chuhong;Hu, Tian;Li, Sai;...

通讯作者：

Wen, Meiling;Zuo, Jianhong

作者机构：

[Tan, Yixi; Zuo, Jianhong; Lv, Xiu; Wen, Meiling; Zhang, Chuhong; Li, Sai; Yan, Hanxing; Hu, Tian; He, Sha] Univ South China, Affiliated Nanhua Hosp, Hengyang 421001, Hunan, Peoples R China.

[Zuo, Jianhong; Lv, Xiu] Univ South China, Sch Med, Hengyang 421001, Hunan, Peoples R China.

[Li, Jincheng] Shaoyang Univ, Med Sch, Shaoyang 422000, Hunan, Peoples R China.

[Lei, Mingsheng] Zhangjiajie City Hosp, Dept Resp & Crit Care Med, Zhangjiajie 427000, Hunan, Peoples R China.

通讯机构：

[Wen, Meiling; Zuo, Jianhong] U

Univ South China, Affiliated Nanhua Hosp, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Angiogenesis;HIF;Hypoxia;Metabolism;VHL

期刊：

基因与疾病

ISSN：

2352-4820

年：

2017

卷：

期：

页码：

19-24

DOI：

10.1016/j.gendis.2016.11.003

基金类别：

This work was supported by National Nature Science Foundation of China (81272960), Key Research Program from Science and Technology Department of Hunan Province, China (2013WK2010 and 2014SK2015). Key Research Program from Ministry of human Resources and Social Security of the People's Republic of China (2016)176.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism. In this review, we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism. Furthermore, we also emphasized the possibility of HIF pathway as a potent...

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The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

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