Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice

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成果类型：

期刊论文

作者：

Shi, Meng Meng;Xu, Xiao Fan;Sun, Qiu Min;Luo, Mingying;Liu, Dan Dan;...

通讯作者：

Xu, Y;Cao, WY

作者机构：

[Shi, Meng Meng; Xu, Xiao Fan; Guo, Dong Min; Cao, Wen Yu] Univ South China, Hengyang Med Sch, Clin Anat & Reprod Med Applicat Inst, Hengyang, Hunan, Peoples R China.

[Sun, Qiu Min] Yiyang Med Coll, Dept Nursing, Yiyang, Hunan, Peoples R China.

[Luo, Mingying] Kunming Med Univ, Dept Anat & Histol & Embryol, Kunming, Yunnan, Peoples R China.

[Zhong, Xiao Lin; Liu, Dan Dan; Chen, Ling] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang, Hunan, Peoples R China.

[Xu, Yang] Univ South China, Hengyang Med Sch, Inst Neurosci, Hengyang, Hunan, Peoples R China.

通讯机构：

[Xu, Y ; Cao, WY ] U

Univ South China, Hengyang Med Sch, Inst Neurosci, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

betaine;cognitive impairment;hippocampus;microglia;social isolation

期刊：

Phytotherapy Research

ISSN：

0951-418X

年：

2023

卷：

期：

页码：

4755-4770

DOI：

10.1002/ptr.7944

基金类别：

National Natural Science Foundation of China [31701045, 81860253]; Hunan Provincial Education Department Foundation of China [19B756]; Project of Yunnan Applied Basic Research-Kunming Medical University Union Foundation [202101AY070001-042]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Chronic social isolation (SI) stress, which became more prevalent during the COVID-19 pandemic, contributes to abnormal behavior, including mood changes and cognitive impairment. Known as a functional nutrient, betaine has potent antioxidant and anti-inflammatory properties in vivo. However, whether betaine can alleviate the abnormal behavior induced by chronic SI in mice remains unknown. In this study, we investigated the efficacy of betaine in the treatment of behavioral changes and its underlying mechanism. Three-week-old male mice were rand...

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Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice

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